Results 71 to 80 of about 31,416 (255)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Assessing the Potential Impact of Changes to the Argo and Moored Buoy Arrays in an Operational Ocean Analysis System

Frontiers in Marine Science, 2020
A series of observing system simulation experiments (OSSEs) have been carried out using the Met Office global Forecasting Ocean Assimilation Model (FOAM) to provide insights on the current and future design of the in situ observing network for ocean ...
Chongyuan Mao, Robert R. King, Rebecca Reid, Matthew J. Martin, Simon A. Good   +4 more
doaj   +1 more source

Observing Systems Simulation Experiments: Their Role in Meteorology

, 1989
Abstract : This report deals with a particular class of simulation experiments - those designed to evaluate the use of data from a given observing system in numerical weather analysis and forecasting. Simulation of data is an attractive option when evaluating a proposed observing system for which no real data are yet available, or when the experiment ...
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Data assimilation in a sparsely observed one-dimensional modeled MHD system [PDF]

Nonlinear Processes in Geophysics, 2007
A one dimensional non-linear magneto-hydrodynamic (MHD) system has been introduced to test a sequential optimal interpolation assimilation technique that uses a Monte-Carlo method to calculate the forecast error covariance.
Z. Sun, A. Tangborn, A. Tangborn, W. Kuang   +3 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Assessing impacts of observations on ocean circulation models with examples from coastal, shelf, and marginal seas

Frontiers in Marine Science
Ocean observing systems in coastal, shelf and marginal seas collect diverse oceanographic information supporting a wide range of socioeconomic needs, but observations are necessarily sparse in space and/or time due to practical limitations.
Christopher A. Edwards, Pierre De Mey-Frémaux, Bàrbara Barceló-Llull, Guillaume Charria, Byoung-Ju Choi, George R. Halliwell, Lars R. Hole, Colette Kerry, Vassiliki H. Kourafalou, Alexander L. Kurapov, Andrew M. Moore, Baptiste Mourre, Baptiste Mourre, Paolo Oddo, Ananda Pascual, Moninya Roughan, Chafih Skandrani, Andrea Storto, Vassilios Vervatis, John L. Wilkin   +19 more
doaj   +1 more source

Observing System Simulation Experiments (OSSEs) for the Mid-Columbia Basin [PDF]

, 2011
The overall goal of this multi-phased research project known as WindSENSE is to develop an observation system deployment strategy that would improve wind power generation forecasts. The objective of the deployment strategy is to produce the maximum benefit for 1- to 6-hour ahead forecasts of wind speed at hub-height ({approx}80 m). In this phase of the
Zack, J, Natenberg, E J, Knowe, G V, Waight, K, Manobianco, J, Hanley, D, Kamath, C   +6 more
openaire   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source