Results 51 to 60 of about 31,416 (255)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A preliminary assessment of the value and impact of multiple configurations of constellations of EON-MW, a proposed 12U microwave sounder CubeSat for global NWP

Tellus: Series A, Dynamic Meteorology and Oceanography, 2021
Observing system assessments were made for the Earth Observing Nanosatellite-Microwave (EON-MW), a 12U CubeSat analog of the Advanced Technology Microwave Sounder (ATMS).
Yan Zhou, Narges Shahroudi, Tong Zhu, Flavio Iturbide-Sanchez, Eric S. Maddy, Sid-Ahmed Boukabara, Kayo Ide, Ross N. Hoffman   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Observing System Impact on Ionospheric Specification Over China Using EnKF Assimilation

Space Weather, 2020
Accurate ionospheric specification for the current and future is one of the key tasks in operational space weather. In this work, we have assessed the effect of a dense ground network consisting of different radio instruments either developed or under ...
Jianhui He, Xinan Yue, Lianhuan Hu, Junyi Wang, Mingyuan Li, Baiqi Ning, Weixing Wan, Jiyao Xu   +7 more
doaj   +1 more source

Assessing the impact of multiple altimeter missions and Argo in a global eddy-permitting data assimilation system [PDF]

Ocean Science, 2017
A series of observing system simulation experiments (OSSEs) is carried out with a global data assimilation system at 1∕4° resolution using simulated data derived from a 1∕12° resolution free-run simulation.
S. Verrier, S. Verrier, P.-Y. Le Traon, P.-Y. Le Traon, E. Remy   +4 more
doaj   +1 more source

An Observing System Simulation Experiment with a Constellation of Radio Occultation Satellites [PDF]

Monthly Weather Review, 2018
Abstract Experiments with a global observing system simulation experiment (OSSE) system based on the recent 7-km-resolution NASA nature run (G5NR) were conducted to determine the potential value of proposed Global Navigation Satellite System (GNSS) radio occultation (RO) constellations in current operational numerical weather prediction ...
R. Atlas, L. Cucurull, R. Li, M. J. Mueller, R. N. Hoffman   +4 more
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evaluating Radio Occultation (RO) Constellation Designs Using Observing System Simulation Experiments (OSSEs) for Ionospheric Specification

Space Weather
Low Earth orbit (LEO) radio occultation|radio occultations (RO) constellations can provide global electron density profiles (EDPs) to better specify and forecast the ionosphere‐thermosphere (I‐T) system.
Nicholas Dietrich, Tomoko Matsuo, Chi‐Yen Lin, Brandon diLorenzo, Charles Chien‐Hung Lin, Tzu‐Wei Fang   +5 more
doaj   +1 more source