Results 41 to 50 of about 31,416 (255)
The effect of using limited scene-dependent averaging kernels approximations for the implementation of fast observing system simulation experiments targeted on lower tropospheric ozone [PDF]
Atmospheric Measurement Techniques, 2013 Practical implementations of chemical OSSEs (Observing System Simulation Experiments) usually rely on approximations of the pseudo-observations by means of a predefined parametrization of the averaging kernels, which describe the sensitivity of the ...
P. Sellitto +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Observing System Simulation Experiments in the Marmara Sea
, 2018 Poster presented in Symposium for the legacy of Anna Trevisan in Bologna in Oct ...
Aydogdu, Ali +9 more
openaire +1 more source
Community Global Observing System Simulation Experiment (OSSE) Package (CGOP): Perfect Observations Simulation Validation [PDF]
Journal of Atmospheric and Oceanic Technology, 2018 AbstractThe simulation of observations—a critical Community Global Observing System Simulation Experiment (OSSE) Package (CGOP) component—is validated first by a comparison of error-free simulated observations for the first 24 h at the start of the nature run (NR) to the real observations for those sensors that operated during that period.
Sid-Ahmed Boukabara +9 more
openaire +1 more source
Parameter Sensitivity of the WRF–LETKF System for Assimilation of Radar Observations: Imperfect-Model Observing System Simulation Experiments [PDF]
Weather and Forecasting, 2020 AbstractSpecification of suitable initial conditions to accurately forecast high-impact weather events associated with intense thunderstorms still poses a significant challenge for convective-scale forecasting. Radar data assimilation has been showing encouraging results to produce an accurate estimate of the state of the atmosphere at the mesoscale ...
Maldonado, Paula Soledad +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2022 The produced data in the single-column observation assimilation experiments and the WRFOUT data produced in the observing system simulation experiments.
openaire +2 more sources