Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Neural Network-Based Temporal Ensembling of Water Depth Estimates Derived from SuperDove Images
CubeSats provide a wealth of high-frequency observations at a meter-scale spatial resolution. However, most current methods of inferring water depth from satellite data consider only a single image.
Milad Niroumand-Jadidi +2 more
doaj +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Observing Suppliers observing Early Supplier Involvement: An Empirical Research based upon the Social Systems Theory of Niklas Luhmann. [PDF]
supplier, involvement ...
Vos, J.P.
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Real-time systems development with SDL and next generation validation tools [PDF]
The language SDL has long been applied in the development of various kinds of systems. Real-time systems are one application area where SDL has been applied extensively.
Sinnott, R.O., Sinnott, Richard O.
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Potential Economic Benefits of Integrated and Sustainable Ocean Observation Systems: The Southeast Atlantic Region [PDF]
The South East Atlantic Coastal Ocean Observing System (SEACOOS) collects, manages and disseminates coastal oceanic and atmospheric observation information along the Atlantic coast of the southeastern United States.
Christopher F. Dumas, John C. Whitehead
core
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Monitoring ocean heat content from the current generation of global ocean observing systems
Variations in the world's ocean heat storage and its associated volume changes are a key factor to gauge global warming and to assess the Earth's energy budget.
K. Schuckmann +7 more
semanticscholar +1 more source

