Results 41 to 50 of about 916,759 (296)
FAM111A protects replication forks from protein obstacles via its trypsin-like domain
Nature Communications, 2020 Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a ...
Yusuke Kojima +6 more
semanticscholar +1 more source
Ocean Engineering, 2020 In this research, a hybrid approach for global path planning for Maritime Autonomous Surface Ship (MASS) is proposed, which generates the shortest path considering the collision risk and the proximity between path and obstacles.
Pengfei Chen +4 more
semanticscholar +1 more source
Confronting the Care Delivery Challenges Arising from Precision Medicine
Frontiers in Oncology, 2016 Understanding the biology of cancer at the cellular and molecular levels, and the application of such knowledge to the patient, has opened new opportunities and uncovered new obstacles to quality cancer care delivery. Benefits include our ability to now
S. Percy Ivy, Elise C. Kohn
doaj +1 more source
Frontiers in Education, 2020 The introduction of sustainability education into the educational reality in recent decades to raise student’s awareness of environmental, social and cultural issues has gradually led to a change in the perception of school as an organization at all ...
Konstantinos Kougias +1 more
doaj +1 more source
Turkish EFL teachers' attitudes towards online instruction throughout the Covid-19 outbreak
English Language Teaching Educational Journal, 2021 The purpose of the present study is to shed light on the attitudes of Turkish EFL teachers towards online instruction (OI), the impact of training on their attitudes, the obstacles they encounter, and the strategies to deliver OI more successfully ...
Mustafa Civelek +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Practical Obstacles to Deploying Active Learning [PDF]
Conference on Empirical Methods in Natural Language Processing, 2018 Active learning (AL) is a widely-used training strategy for maximizing predictive performance subject to a fixed annotation budget. In AL, one iteratively selects training examples for annotation, often those for which the current model is most uncertain
David Lowell +2 more
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
MISTRUST AND DOUBT IN CLOUD ACCOUNTING [PDF]
Annals of the University of Craiova: Economic Sciences Series, 2022 Cloud computing is an innovation that promises flexibility and savings for the company's IT department. On the other hand, its penetration into the accounting industry makes it to be perceived as something that threatens the existence of this occupation.
Cristian Dragoș Țurcan +3 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source