Results 91 to 100 of about 159,829 (340)

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Diagnostic yield of expanded carrier screening of a multi-ethnic population in yunnan, China

Scientific Reports
Rare genetic diseases are responsible for a small but significant proportion of childhood morbidity and mortality. The majority of these diseases have no treatment and they create a huge burden on the families and the whole society.
Huizi Wang, Quxi Zhao, Dongping Xie, Jinbi Peng, Guixian Chen, Xudong Dong   +5 more
doaj   +1 more source

De geschiedenis van de veterinaire verloskunde [PDF]

, 2011
Extraction, reposition, fetotomy (embryotomy) and even cesarean section have been part of human and animal obstetrics since ancient times. Destructive operations like craniotomy and embryotomy are the oldest type of obstetrical operations. At the end of
de Kruif, Aart
core  

Contemporary and Historical Evidence to Suggest that Women’s Preference for Age at Birth of First Child Remains Consistent Across Time [PDF]

, 2014
Women’s ability to reproduce is restricted by menarche and menopause. First children are, however, not typically born until some years after the onset of puberty. Other factors therefore contribute towards this delay. In this context, women’s hips do not
Brewer, Gayle, Hendrie, Colin A., Lewis, Hannah, Mills, Francesca   +3 more
core   +2 more sources

Fistula after attended delivery and the challenge of obstetric care capacity in the eastern Democratic Republic of Congo [PDF]

, 2015
Nerys Benfield, Nichole Young‐Lin, Christophe Kimona, Luc Malemo Kalisya, R.M. Kisindja   +4 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Association of urinary misfolded protein quantification with preeclampsia and adverse pregnancy outcomes: a retrospective case study

Journal of Perinatal Medicine
This study aimed to explore the relationship between the detection of misfolded proteins in urine and preeclampsia (PE) as well as adverse pregnancy outcomes.
Zhao Shuang, Zhang Mingju, Yang Jingyuan, Du Zhuoran, Wang Guohui, Shan Shufan   +5 more
doaj   +1 more source

A study to determine the effectiveness of cleanliness measures by mothers in preparation for handling of feeding their infants [PDF]

, 1958
Thesis (M.S.)--Boston ...
Lau, Evelyn Babs
core   +1 more source