Results 101 to 110 of about 65,642 (314)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Psychosocial aspects during pregnancy and obstetrical complications

, 1985
A test for measuring the capacity of women to face the obstetrical difficulties was applied to a sample of women during purperium. Groups of differently-capable women to face difficulties were detected with an automatic interaction detector ...
COSENTINO M., ANDREOLI F, MAGNI G, Michele Cosentino, Guido Magni, ANDREOLI C, Francesca Andreoli, Giselda Martinotti, Gregorio Merlin, MARTINOTTI G, Cesare Andreoli, Renzo Rizzardo, RIZZARDO R, FABBRIS, LUIGI, Luigi Fabbris, MERLIN G   +15 more
core   +1 more source

Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus

Nature Communications
Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnancy, but the underlying mechanism has not been fully clarified. Using metabolomic profiling of second-trimester saliva, serum, and urine, we identify 54 metabolites altered in ...
Qi Wu, Yihui Wu, Shuqi Zhu, Yibo Tang, Lixia Zhang, Jiayue Tang, Qi Chen, Luyao Hu, Pingya Zhu, Xuliang Fu, Jianghai Chang, Sheng Cao, Danqing Chen, Zhaoxia Liang   +13 more
doaj   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Obstetrical characteristics of women with and without gynecological disorders.

, 2019
Obstetrical characteristics of women with and without gynecological disorders.
Kunihiko Hayashi (2525962), Tasuku Harada (3599492), Youichi Kurozawa (3599495), Takashi Harada (1520857), Yuki Ideno (3568010), Hiroki Amano (7124273), Fuminori Taniguchi (3599498)   +6 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

An obstetrical emergency management quality improvement project

, 2015
Obstetrical emergencies occur in approximately 5% of births necessitating immediate interventions to prevent catastrophic consequences. A knowledge deficit specific to obstetrical emergencies was the impetus for this project.
Montgomery, Penny
core  

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Relative Risk of Obstetrical Complications and Neonatal Outcomes.

, 2016
Relative Risk of Obstetrical Complications and Neonatal Outcomes.
Kunihiko Hayashi (2525962), Tasuku Harada (3599492), Youichi Kurozawa (3599495), Takashi Harada (1520857), Kazunari Onishi (3599489), Fuminori Taniguchi (3599498)   +5 more
core   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source