Results 31 to 40 of about 766,034 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

An integrative review on women living with obstetric fistula and after treatment experiences [PDF]

open access: yes, 2017
Aims and objectives. To review literature on the experiences of women with obstetric fistula, their lived experiences after treatment; and to provide evidence for future research. Background.
Hayter, Mark   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Obstetric use of nitroglycerin: Anesthetic implications

open access: yesSaudi Journal of Anaesthesia, 2013
Nitroglycerin has been used in anesthetic practice for induced hypotension and managing perioperative hypertension and myocardial ischemia. Contrary to the continuous low dose infusions (5-20 mcg/min) used for the same, intravenous bolus dosages are ...
Richa Saroa   +4 more
doaj   +1 more source

Analysis of maternal mortality in Jammu and Kashmir: A retrospective study based on review of field data

open access: yesAsian Journal of Medical Sciences, 2022
Background: The inequities in provision of essential maternal healthcare have led to significant difference in maternal mortality globally. Having area specific data of maternal deaths are an important prerequisite for strengthening of reproductive and ...
Saleem Ur Rehman   +2 more
doaj   +1 more source

Geospatial Variation in Caesarean Delivery [PDF]

open access: yes, 2020
Aim: The purpose of this study was to evaluate the variation in caesarean delivery rates across counties in Georgia and to determine whether county-level characteristics were associated with clusters. Design: This was a retrospective, observational study.
Dunlop, Anne   +2 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Postcaesarean Surgical Site Infection at a Tertiary Care Centre in Southern Rajasthan, India

open access: yesInternational Journal of Anatomy Radiology and Surgery, 2022
Introduction: Surgical Site Infection (SSI) is one of the most common complications of postcaesarean section, which is mainly associated with increase morbidity and mortality.
Gulshan Bano   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

The role of immunogenetic factors in the aetiology of pre-eclamptic toxaemia of human pregnancy [PDF]

open access: yes, 1978
2 volume setThesis (M.D.) -- University of Adelaide, Dept.
Need, Jillian Ann
core   +1 more source

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