Results 41 to 50 of about 766,034 (314)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Adnexal Torsion in Pediatric Age: Does Bolli's Score Work? Report of Two Cases [PDF]

, 2019
Adnexal torsion is a surgical emergency requiring early diagnosis in order to avoid demolitive surgery. Adnexal torsion's diagnosis could be very difficult in pediatric patients because children cannot explain symptoms accurately.
Borriello, M, Chiantera, V, Giambanco, L, Iannone, V, Scibilia, G, Scollo, P, Sozzi, G   +6 more
core   +1 more source

A comparison of neonatal outcomes between adolescent and adult mothers in developed countries: A systematic review and meta-analysis [PDF]

, 2020
Evidence suggests that adolescent pregnancies are at increased risk of adverse neonatal outcomes compared to adult pregnancies; however, there are significant inconsistencies in the literature, particularly in studies conducted in developed countries ...
Marvin-Dowle, K, Soltani, Hora
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Antenatal screening for TB disease: a systematic review and meta-analysis

IJTLD Open
OBJECTIVES: TB disease during pregnancy is associated with poor maternal and neonatal outcomes, and is a leading non-obstetric cause of maternal death. However, optimal detection strategies remain uncertain.
A.J. Morton, N. Meagher, G. Tonkin-Hill, J.T. Denholm, R.I. Zahroh, S.J. Dunstan   +5 more
doaj   +1 more source

HIV and Pregnancy: A Retrospective Descriptive Cross-sectional Study of Prevalence, Maternal, Obstetrical, and Neonatal Outcome at a Tertiary Care Hospital in Oman

Oman Medical Journal, 2021
Objectives: We sought to investigate the prevalence of HIV in pregnant women and the maternal, obstetrical, and neonatal outcomes over 13 years (2005–2017) at Sultan Qaboos University Hospital, a tertiary hospital in Muscat, Oman.
Nada Ali Salim Al Hasani, Tamima Al Dughaishi, Abdullah A. Balkhair   +2 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

“I honestly didn’t know it was for women too…” acceptability and feasibility of integrating PrEP services into OB/GYN practices from the perspectives of practice staff and cisgender women in the community: a qualitative study

Frontiers in Health Services
BackgroundHIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV but uptake among cisgender women in the United States (US) is suboptimal.
Christine M. Khosropour, Elise Healy, Emma M. Murphy, Arianna Rubin Means, Erykah Pasha, Jaelyn Howard, Emani Gonzalez, Tiffany D. Lloyd, Bethany Spier, Cathy J. Berry, Kandis V. Backus   +10 more
doaj   +1 more source

Emergency Medical Services (EMS) Utilization in Zimbabwe: Retrospective Review of Harare Ambulance System Reports

Annals of Global Health, 2022
Background: Emergency medical services (EMS) are a critical but often overlooked component of essential public health care delivery in low- and middle-income countries (LMICs). Few countries in Africa have established EMS and there is scant literature to
Monalisa Muchatuta, Soman Mudariki, Loretta Matheson, Brian Rice, Midion Chidzonga, Rebecca Walker, Matthew Strehlow, Jennifer Newberry   +7 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source