Results 41 to 50 of about 507,475 (219)

“I honestly didn’t know it was for women too…” acceptability and feasibility of integrating PrEP services into OB/GYN practices from the perspectives of practice staff and cisgender women in the community: a qualitative study

Frontiers in Health Services
BackgroundHIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV but uptake among cisgender women in the United States (US) is suboptimal.
Christine M. Khosropour, Elise Healy, Emma M. Murphy, Arianna Rubin Means, Erykah Pasha, Jaelyn Howard, Emani Gonzalez, Tiffany D. Lloyd, Bethany Spier, Cathy J. Berry, Kandis V. Backus   +10 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Major Factors Contributing to Positive and Negative Childbirth Experiences in Pregnant Women Living with HIV

Behavioral Sciences
Objective: The aim of this study was to assess the opinions of pregnant women living with HIV (PWLWHIV) about their positive childbirth experiences and the most important factors contributing to positive or negative experiences.
Andréa Paula de Azevedo, Luisa Castro, Cristina Barroso Hofer, Francisca Rego   +3 more
doaj   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Analysis of obstetric complications reported to the National Patient Insurance Association in Finland from 1987 to 1995

Acta Obstetricia et Gynecologica Scandinavica, 1997
Background. The launch of the National Patient Insurance Association in 1987 off erred a good starting point to evaluate obstetric claims in Finland. In order to obtain full compensation after patient injury, proof of malpractice is no longer required ...
Tapio Kurki
doaj   +1 more source

“The Presence of a Monstrosity”: Eugenics, Female Disability, and Obstetrical-Gynecologic Medicine in Late 19th-Century New York

Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2017
This article analyzes the connection between eugenics, the professionalization of American medicine, and the development of the specialties of obstetrics and gynecology.
Lauren MacIvor Thompson
doaj   +1 more source

Maternal deaths due to eclampsia in teenagers: Lessons from assessment of maternal deaths in South Africa

African Journal of Primary Health Care & Family Medicine, 2020
Background: Eclampsia remains a major cause of maternal mortality, particularly in teenage pregnancies. Healthcare professionals providing antenatal must regard teenagers as a high risk group for the pre-eclampsia-eclampsia syndrome.
Jagidesa Moodley, Nnabuike C. Ngene
doaj   +1 more source

Towards an affordable magnetomyography instrumentation and low model complexity approach for labour imminency prediction using a novel multiresolution analysis

Applied AI Letters, 2021
The ability to predict the onset of labour is seen to be an important tool in a clinical setting. Magnetomyography has shown promise in the area of labour imminency prediction, but its clinical application remains limited due to high resource consumption
Ejay Nsugbe, Ibrahim Sanusi
doaj   +1 more source

A Scalable Spin‐Coating Strategy for Mesoporous Gold Thin Films toward miRNA Detection

Advanced Science, EarlyView.
A scalable spin‐coating strategy produces uniform mesoporous Au thin films with tunable thickness and high electroactive surface area on transparent substrates. The resulting architecture enables label‐free, amplification‐free detection of ovarian cancer‐associated miRNA hsa‐miR‐200c‐3p from 1 aM to 10 pM, achieving a 1.72 aM detection limit with high ...
Aditya Ashok, Emtiaz Ahmed, Arya Vasanth, Mandy Hei Man Leung, Miharu Eguchi, Md Shahriar A. Hossain, Mostafa Kamal Masud, Carlos Salomon, Yusuke Yamauchi   +8 more
wiley   +1 more source