Results 61 to 70 of about 479,851 (266)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Identification of Key Mitochondrial Autophagy-Related Genes in Fetal Growth Restriction

International Journal of Women's Health
Yanru Yao, Gang Lei, Guangxin Pan, Guoping Xiong, Jian Shen Obstetric, Centre Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hubei, 430014, People’s Republic of ChinaCorrespondence: Guoping Xiong, Obstetric, Centre Hospital of ...
Yao Y, Lei G, Pan G, Xiong G, Shen J
doaj  

Obstetric claims in Finland 2012–2022—A nationwide patient insurance registry study

Acta Obstetricia et Gynecologica Scandinavica
Introduction Maternal and infant mortality rates in Finland are among the lowest in the world, yet preventable obstetric injuries occur every year. The aim of this study was to describe obstetric claims, their compensation rates, and temporal trends of ...
Jaana Lojander, Maiju Welling, Anna Axelin, Marja Härkänen, Juho Kopra, Reeta Lamminpää   +5 more
doaj   +1 more source

Implementation challenges in preeclampsia care: perspectives from health care professionals in urban UgandaAJOG MFM at a Glance

AJOG Global Reports
BACKGROUND: Sub-Saharan Africa bears the burden of 70% of maternal deaths worldwide, of which ∼10% are attributable to hypertensive disorders of pregnancy, primarily complications of preeclampsia.
Imelda Namagembe, MD, Babu Karavadra, BSc Hons, MBBS, PhD, Lawrence Kazibwe, MBChB, MMed, Joseph Rujumba, PhD, Noah Kiwanuka, MBChB, MPH, PhD, Brandon Smith, BSc Hons, PhD, Josaphat Byamugisha, PhD, Ashley Moffett, MB/BChir, PhD, Tom Bashford, MBBS, MBiochem, PhD, MRCP, FRCA, Annettee Nakimuli, MD, PhD, Catherine E. Aiken, MB/BChir, MA, PhD, MRCOG, MRCP   +10 more
doaj   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia

Journal of Inflammation Research
Yanxuan Xiao,1,2,* Maliang Tao,3,* Yiqi Yu,1,* Ruiyan Bai,1,2 Yunting Zhuang,1,2 Qiuyu Huang,1 Jiexing He,1 Zeshan Lin,1,2 Mingze Gao,1 Jiaqi Li,1 Yuting Wang,1 Yao Xu,1 Xinyang Shen,1 Zhenqin Huang,1 Yuan Yao,1 Zhiyong Chen,1 ...
Xiao Y, Tao M, Yu Y, Bai R, Zhuang Y, Huang Q, He J, Lin Z, Gao M, Li J, Wang Y, Xu Y, Shen X, Huang Z, Yao Y, Chen Z, Chen Q, Wang Z   +17 more
doaj  

Incidence of stillbirth among women with different risk profiles in Stockholm 2001–2020: a repeated cross‐sectional study

Acta Obstetricia et Gynecologica Scandinavica
Introduction The incidence of stillbirth in Sweden has started to decline. However, some comparable high‐income countries in Europe have an even lower incidence, indicating a potential for further reduction.
Minna Lundén, Ingela Hulthén Varli, Helena Kopp Kallner, Hanna Åmark   +3 more
doaj   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Late Preschool BMI Acceleration as the Strongest Predictor of Childhood Cardiometabolic Risk at School Entry: A Dual-Trajectory Cohort Study

Diabetes, Metabolic Syndrome and Obesity
Shuang Zhang, Jinnan Liu, Weiqin Li, Jing Wang, Yijuan Qiao, Tao Zhang, Wei Dong, Junhong Leng, Lingyan Feng Tianjin Women and Children’s Health Center, Tianjin, People’s Republic of ChinaCorrespondence: Lingyan Feng, Tianjin Women and Children’s Health ...
Zhang S, Liu J, Li W, Wang J, Qiao Y, Zhang T, Dong W, Leng J, Feng L   +8 more
doaj  

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source