Results 61 to 70 of about 482,244 (316)

Implementation challenges in preeclampsia care: perspectives from health care professionals in urban UgandaAJOG MFM at a Glance

AJOG Global Reports
BACKGROUND: Sub-Saharan Africa bears the burden of 70% of maternal deaths worldwide, of which ∼10% are attributable to hypertensive disorders of pregnancy, primarily complications of preeclampsia.
Imelda Namagembe, MD, Babu Karavadra, BSc Hons, MBBS, PhD, Lawrence Kazibwe, MBChB, MMed, Joseph Rujumba, PhD, Noah Kiwanuka, MBChB, MPH, PhD, Brandon Smith, BSc Hons, PhD, Josaphat Byamugisha, PhD, Ashley Moffett, MB/BChir, PhD, Tom Bashford, MBBS, MBiochem, PhD, MRCP, FRCA, Annettee Nakimuli, MD, PhD, Catherine E. Aiken, MB/BChir, MA, PhD, MRCOG, MRCP   +10 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Identification of Key Mitochondrial Autophagy-Related Genes in Fetal Growth Restriction

International Journal of Women's Health
Yanru Yao, Gang Lei, Guangxin Pan, Guoping Xiong, Jian Shen Obstetric, Centre Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hubei, 430014, People’s Republic of ChinaCorrespondence: Guoping Xiong, Obstetric, Centre Hospital of ...
Yao Y, Lei G, Pan G, Xiong G, Shen J
doaj  

Incidence of stillbirth among women with different risk profiles in Stockholm 2001–2020: a repeated cross‐sectional study

Acta Obstetricia et Gynecologica Scandinavica
Introduction The incidence of stillbirth in Sweden has started to decline. However, some comparable high‐income countries in Europe have an even lower incidence, indicating a potential for further reduction.
Minna Lundén, Ingela Hulthén Varli, Helena Kopp Kallner, Hanna Åmark   +3 more
doaj   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Abortion providers in the United States: expanding beyond obstetrics and gynecology

, 2023
Kareena Sagar, Erica Rego, Radhika Malhotra, Amanda Lacue, Kristyn Brandi   +4 more
openalex   +1 more source

Understanding trends in current obstetrics & gynecology resident exposure to subspecialty training [PDF]

, 2023
S.M. Murarka, S. Nelamangala, N. Ravichandran, M.V. Baker, U.R. Omosigho, N.C. White, C. Zimmerman   +6 more
openalex   +1 more source