Results 71 to 80 of about 754,352 (360)

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Evaluating the Correlation of Systemic Inflammatory Response Syndrome with Mortality and Morbidity in Critically Ill Obstetric Patients in ICU

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010
Background and Objectives: Systemic inflammatory response syndrome (SIRS) is a relatively accurate predictor of outcome in critically ill patients treated in medical/surgical ICU.
M Jabalameli, Shahshahan, AR Azizian
doaj  

Non-Clinical Variables Influencing Cesarean Section Rate According to Robson Classification

Medicina, 2020
Background and Objectives: The incidence of cesarean section (CS) has progressively increased worldwide, without any proven benefit to either the mother or the newborn.
Noemi Strambi, Flavia Sorbi, Gian Marco Bartolini, Chiara Forconi, Giovanni Sisti, Viola Seravalli, Mariarosaria Di Tommaso   +6 more
doaj   +1 more source

Contemporary and Historical Evidence to Suggest that Women’s Preference for Age at Birth of First Child Remains Consistent Across Time [PDF]

, 2014
Women’s ability to reproduce is restricted by menarche and menopause. First children are, however, not typically born until some years after the onset of puberty. Other factors therefore contribute towards this delay. In this context, women’s hips do not
Brewer, Gayle, Hendrie, Colin A., Lewis, Hannah, Mills, Francesca   +3 more
core   +2 more sources

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer

Advanced Science, EarlyView.
PAD1 is upregulated within the CD133+ subset or cisplatin‐resistant ovarian cancer cells, which is positively associated with the upregulation of stemness‐related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1‐catalyzed AKT2 citrullination at R202 facilitates AKT2 phosphorylation, promoting CEBPβ expression and its binding to the ...
Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei, Jian Gu, Yun Han, Jia Xing, Xiaohan Liu, Fei Liang, Paul R Thompson, Xuesen Zhang   +10 more
wiley   +1 more source

The Great Medical Malpractice Hoax: NPDB Data Continue to Show Medical Liability System Produces Rational Outcomes [PDF]

, 2007
Despite claims by business and medical lobbying interests and the Bush administration, there is no medical malpractice lawsuit crisis in America, according to this report by Public Citizen.
Lara Chausow, Seth Oldmixon
core  

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

What explains variation in the costs of treating patients in English obstetrics specialties? [PDF]

We assess patients admitted to English obstetrics departments to identify what proportion of variation in their costs is explained by patient characteristics and what proportion is due to departmental characteristics.
Andrew Street, Kim Rosen Olsen, Mauro Laudicella   +2 more
core  

Management of severe epistaxis during pregnancy: a case report and review of the literature [PDF]

, 2019
Epistaxis is a common problem during pregnancy. Few cases of severe epistaxis, not associated with nasal lesions or clotting disorders, were described in the literature.
Brunelli, Roberto, Derme, Martina, Morrocchi, Elisa, Pecorini, Francesco, Piccioni, Maria Grazia, Porpora, Maria Grazia, Salerno, Laura   +6 more
core   +1 more source