Results 161 to 170 of about 904,486 (315)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mandibular Advancement for Obstructive Sleep Apnea: Efficacy and the Trade-off of Expiratory Velopharyngeal Obstruction During Sleep Endoscopy - An Exploratory Observational Study. [PDF]

Nat Sci Sleep
Lo SC, Hsu YS, Lin YH, Kuo YE, Chen TY, Yang CCH.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Conservative Pediatric Duodenal Obstruction After Seatbelt Trauma: Why Monitoring Should Include Predefined Escalation Criteria, Not Gastric Tube Output Alone. [PDF]

Clin Case Rep
Awan MA.
europepmc   +1 more source

Perceived Challenge, Teacher Support, and Teacher Obstruction as Predictors of Student Engagement

, 2017
Anna D. Strati, Jennifer A. Schmidt, Kimberly S. Maier   +2 more
semanticscholar   +1 more source

Development of a shuttle walking test of disability in patients with chronic airways obstruction.

Thorax, 1992
Sally, M. S. Singh, M. D. L. Morgan, Shona Scott, D. Walters, A. Hardman   +5 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Appendiceal band syndrome causing acute small bowel obstruction with concomitant appendicitis: a case report. [PDF]

J Surg Case Rep
Hassan AI, Hassan HA, Elmi AM, Omar AA, Bashir AM, Nur NM.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Incidental Coronary Sinus Stenosis During Coronary Angiography: A Rare Angiographic Finding. [PDF]

Case Rep Cardiol
Faradonbeh NA, Khalilipur E, Yarahmadi M, Shamsedini A.   +3 more
europepmc   +1 more source