Results 41 to 50 of about 713,036 (258)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution

Respiratory Research
Introduction Diesel exhaust particles (DEP) have been proven to aggravate asthma pathogenesis. We previously demonstrated that concurrent exposure to house dust mite (HDM) and DEP in mice increases both eosinophils and neutrophils in bronchoalveolar ...
Joyceline De Volder, Annelies Bontinck, Valerie Haelterman, Louis Boon, Guy F. Joos, Guy G. Brusselle, Tania Maes   +6 more
doaj   +1 more source

Long-acting beta2-agonists for chronic obstructive pulmonary disease. [PDF]

, 2013
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes progressive symptoms of breathlessness, cough and mucus build-up.
Walters, JA, Chris Mavergames, Kew, KM, Mavergames, C, Kayleigh M Kew, Julia AE Walters   +5 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Optimized culture of primary human alveolar type II cell–derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling

Respiratory Research
Background Alveolar type II (AT-II) epithelial cells are essential for alveolar repair, immune regulation, and surfactant secretion. Despite their promise for pulmonary disease modeling, limited access and culture methods hinder translational use.
Lara-Jasmin Schröder, Julia Rückoldt, Stephanie Schubert, Lars Knudsen, Sabina-Marija Janciauskiene, Christopher Werlein, Mareike Knoll, Regina Engelhardt, Christina Petzold-Mügge, Jonas C. Schupp, Marius M. Hoeper, Jens Gottlieb, Fabio Ius, Patrick Zardo, Marc Lindenberg, Christian Riehle, Lavinia Neubert, Jan C. Kamp   +17 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Avaliação dos níveis séricos de testosterona em pacientes com síndrome da apneia obstrutiva do sono Evaluation of testosterone serum levels in patients with obstructive sleep apnea syndrome

Brazilian Journal of Otorhinolaryngology, 2011
Homens com síndrome da apneia obstrutiva do sono (SAOS) podem apresentar diminuição dos níveis de testosterona devido à hipóxia. OBJETIVOS: Relacionar os níveis séricos da testosterona, em pacientes com SAOS, com parâmetros clínico-laboratoriais ...
Fernando Drimel Molina, Marcela Suman, Thiago Bittencourt Ottoni de Carvalho, Vânia Belintani Piatto, Sebastião Roberto Taboga, José Victor Maniglia, Waldir Antônio Tognola   +6 more
doaj   +1 more source

Obstructive Sleep Apnoea: a dental perspective [PDF]

, 2003
Obstructive sleep apnoea (OSA) is regarded as a potentially life threatening breathing disorder characterised by periodic cessation of air intake during sleep.
Mulligan, Kevin M.
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Pharyngeal Airspace Alterations after Using the Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea Syndrome

Life, 2022
Background: Mandibular Advancement Devices (MADs), inserted in non-surgical treatments for obstructive sleep apnea and hypopnea syndrome (OSAHS), are used intra-orally during the sleep period, with the aim of promoting mandibular protrusion.
Pedro Dias Ferraz, Inês Francisco, Maria Inês Borges, Adriana Guimarães, Fátima Carvalho, Francisco Caramelo, José Pedro Figueiredo, Francisco Vale   +7 more
doaj   +1 more source