Results 41 to 50 of about 9,136 (172)

Chromosomal disorders and male infertility [PDF]

, 2015
Male factor infertility is considered a complex disorder with a largely unknown etiology that affects about 7% of men. In general, genetic abnormalities account for 15%-30% of condition and Y chromosome microdeletions are also frequent.
Alves, C., Ambrósio, P., Brito, F., Caetano, I., Correia, H., Geraldes, M.C., Gonçalves, J., Marques, B., Pedro, S., Serafim, S., Silva, M., Simão, L.   +11 more
core  

Experience in Optimising Fertility Outcomes in Men with Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency. [PDF]

, 2016
OBJECTIVE: Men with congenital adrenal hyperplasia (CAH) have impaired fertility. We aimed to assess fertility outcomes and the importance of hypogonadotropic hypogonadism, testicular failure and the presence of testicular adrenal rest tumours (TART ...
Arlt, Bouvattier, Cabrera, Casteràs, Claahsen-van der Grinten, Claahsen-van der Grinten, Claahsen-van der Grinten, Claahsen-van der Grinten, Claahsen-van der Grinten, Claahsen-van der Grinten, Collet, Cooper, Delfino, Falhammar, Foresta, Gleeson, Han, Han, Keely, McLachlan, Ogilvie, Reisch, Reisch, Sikaris, Stikkelbroeck, Takihara, Urban, Vanzulli, Wilkins, Wischusen   +29 more
core   +1 more source

Use of Pentoxifylline to Improve Seminal Parameters in Dogs

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
A single oral dose of pentoxifylline (10 mg/kg) administered 40 min before ejaculation significantly improved sperm concentration and progressive motility in dogs. The effect was most pronounced in oligospermic subjects, supporting pentoxifylline as a rapid, well‐tolerated adjunct therapy for canine subfertility .
Vincenzo Cicirelli, Matteo Burgio, Lorenza Frattina, Francesco Caprio, Domenico Robbe, Federica Ariu, Annalisa Rizzo   +6 more
wiley   +1 more source

Male infertility [PDF]

, 2012
published_or_final_versio
Ho, PC, Lee, VCY, Ng, EHY
core  

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia [PDF]

, 2011
The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT).
Dohle, G.R. (Gert), Ghanem, M.A.I. (Mazen), Ghanem, M.A.I. (Mazen), Safan, M.A. (Manal A.)   +3 more
core   +1 more source

Pharmacogenetics of follicle‐stimulating hormone action in the male

Andrology, Volume 14, Issue 4, Page 1064-1072, May 2026.
Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani, Giuseppe Grande, Raffele Scafa, Riccardo Selice, Andrea Garolla, Maria Santa Rocca, Cinzia Vinanzi, Alberto Ferlin   +7 more
wiley   +1 more source

STAG3 is a strong candidate gene for male infertility [PDF]

, 2014
Oligo- and azoospermia are severe forms of male infertility. However, known genetic factors account only for a small fraction of the cases. Recently, whole-exome sequencing in a large consanguineous family with inherited premature ovarian failure (POF ...
Barbero, José Luis, Caburet, Sandrine, García-Tuñón, Ignacio, Gomez-H, Laura, Llano, Elena, Pendás, Alberto M., Schimenti, John, Sánchez-Martín, M., Veitia, Reiner A.   +8 more
core   +3 more sources

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, Volume 13, Issue 22, 17 April 2026.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Altered expression of aromatase, estrogen receptors and progesterone receptors in human leydig cell hyperplasia [PDF]

, 2015
Testicular function is regulated by pituitary hormones and also by paracrine and autocrine factors. A number of reports have pointed out the importance of estrogens and progesterone in male reproductive tract.
Calandra, Ricardo Saul, Gonzalez de Calvar, Silvia Ines, Gonzalez, Candela Rocio, Inserra, Pablo Ignacio Felipe, Levalle, Oscar, Ponzio, Roberto Oscar, Puigdomenech, Elisa, Terradas, Claudio, Vitullo, Alfredo Daniel   +8 more
core   +2 more sources

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source