Obstructive sleep apnoea - Open Access .click

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Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano +6 more
wiley +1 more source

Peculiarities of endoscopic tuboplastics in syndrome of obstructive sleep apnoea and pathology of the middle ear in children

Медицинский совет, 2016
This article covers the issue of diagnostics and method of surgical therapy of such reason of the middle exudative otitis and syndrome of the obstructive sleep apnoea as hypertrophy of the tubal rollers and hyperplasia of tubal tonsils.
Y. Y. Rusetsky +4 more
doaj +1 more source

Semaglutide vs. liraglutide and incidence of diabetes and cardiovascular disease: A target trial emulation using real‐world data

British Journal of Clinical Pharmacology, EarlyView.
Aims The glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) semaglutide and liraglutide are approved for chronic weight management. Both drugs also have favourable effects on the risk of developing diabetes and cardiovascular disease (CVD) compared with placebo, but their comparative effectiveness for these outcomes is unclear.
Ethan J. Cannon +7 more
wiley +1 more source

Identifying Excessive Daytime Sleepiness Using Epworth Sleepiness Scale in a Normal Healthy Population – A Pilot Study

Journal of Clinical and Biomedical Sciences, 2018
Introduction: Excessive daytime sleepiness (EDS) is a common sign in obstructive sleep apnoea syndrome which is often missed during routine screening. Epworth Sleepiness Scale (ESS) is simple, reliable tool to assess daytime sleepiness.
Sriram SP, Vinutha Shankar MS, Shobha MV +2 more
doaj +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza +12 more
wiley +1 more source

Obstructive Sleep Apnoea Syndrome: Continuous Positive Airway Pressure Therapy for Prevention of Cardiovascular Risk

European Cardiology Review, 2020
Obstructive sleep apnoea (OSA) syndrome is characterised by the presence of apnoea or obstructive hypopnoea during sleep, accompanied by hypoxia. It is estimated that the syndrome affects approximately 10% of men and 15% of women. Diagnosis and treatment
María Pilar Resano-Barrio +3 more
doaj +1 more source

Childhood obstructive sleep apnoea [PDF]

BMJ, 2005
Serious neurobehavioural sequelae have prompted interest in diagnosis and management O bstructive sleep apnoea is characterised by oxygen desaturation and reduced oro-nasal air flow despite preserved thoracic and abdominal respiratory effort.1 It occurs in 1-2% of children and is more common in prematurely born infants and in black and Hispanic ...
openaire +2 more sources

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković +5 more
wiley +1 more source

Comparative effects of moderate-intensity interval training on sleep quality and functional capacity in atrial fibrillation patients with two types of sleep apnea

Physiotherapy Quarterly
Introduction This study aimed to examine the effects of moderate-intensity interval training (MIIT) on the quality of sleep and functional capacity in atrial fibrillation (AF) patients with different presentations of sleep apnoea after coronary artery ...
Hady Atef +4 more
doaj +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor +11 more
wiley +1 more source

medicine
diseases of the respiratory system
polysomnography

sleep apnoea