Effectiveness, tolerability and safety of Direct Acting Antivirals in Mexican individuals with Hepatitis C virus genotype-1 and previous pegylated interferon and ribavirin therapy [PDF]
PeerJ, 2021 Background Direct Acting Antivirals (DAAs) represent a large improvement in the treatment of chronic hepatitis C, resulting in
Daniel Melendez-Mena +16 more
doaj +2 more sources
Recent advances in improving yield and immunity through transcription factor engineering. [PDF]
J Integr Plant BiolRecent advances have demonstrated that modulating transcription factors can help balance growth and immunity, which is critical to achieving high yield and disease resistance in crops. This review provides a perspective on how specific transcription factors can be engineered to enhance growth and immunity simultaneously. ABSTRACT Transcription factors (
Iswanto ABB +5 more
europepmc +2 more sources
Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]
, 2016 The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana +5 more
core +1 more source
Журнал инфектологии, 2017 Interferon-free therapy for genotype 1 hepatitis C are preferable from the point of view of clinical effectiveness and safety.The purpose of work was the assessment of costs and costeffectiveness of regimens for the treatment of HCV (1 genotype) at the ...
A. V. Rudakova +4 more
doaj +1 more source
Structural olfactory nerve changes in patients suffering from idiopathic intracranial hypertension. [PDF]
PLoS ONE, 2012 BACKGROUND: Complications of idiopathic intracranial hypertension (IIH) are usually caused by elevated intracranial pressure (ICP). In a similar way as in the optic nerve, elevated ICP could also compromise the olfactory nerve system.
Christoph Schmidt +7 more
doaj +1 more source
Journal of Medicine in Scientific Research, 2021 Background and aim Infection with hepatitis C virus (HCV) is an important cause of mortality and morbidity in patients with end-stage renal disease. Direct-acting antiviral drugs allow for the treatment of this group of patients.
Muhammad M A. Ghaffar +2 more
doaj +1 more source
Isolated Fallopian Tube Torsion
Case Reports in Obstetrics and Gynecology, 2013 Isolated torsion of the Fallopian tube is a rare gynecological cause of acute lower abdominal pain, and diagnosis is difficult. There are no pathognomonic symptoms; clinical, imaging, or laboratory findings.
S. Kardakis +5 more
doaj +1 more source
Журнал инфектологии, 2018 Interferon-free therapy for genotype 1 hepatitis C is highly effective at any severity of liver fibrosis. The purpose of work was to assess cost-effectiveness and the budget impact of paritaprevir/ombitasvir/dasabuvir/ ritonavir (PTV/OBV/DSV/r ...
A. V. Rudakova +4 more
doaj +1 more source
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]
, 2015 One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A. +2 more
core +2 more sources
Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]
, 2012 A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P +12 more
core +3 more sources