Results 81 to 90 of about 21,507 (222)

A Quantitative Systems Pharmacology (QSP) Model of Acute Hepatitis B Virus Infection: Mechanistic Insights and Foundations for Future Extensions

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a significant global health challenge. While the dynamic interplay between viral replication and host immune responses determines infection outcomes, the mechanisms driving the resolution of acute infection versus the emergence of chronicity remain incompletely understood.
Clémence Boivin‐Champeaux, Stephan Schmidt, Scott Balsitis, Francine Johansson Azeredo, Justin S. Feigelman   +4 more
wiley   +1 more source

Prevalence of Occult Hepatitis B Infection Among Blood Donors with HBsAg Negative and HBcAb Positive by Real Time PCR in South of Iran

Armaghane Danesh Bimonthly Journal, 2021
Background & aim: Occult hepatitis B virus infection in blood donors threats the safety of the blood supply.  It is characterized by detection of low viral DNA in the serum subjects who have negative test for Hepatitis B surface antigen (HBsAg).
Alireza Mankhian, Afsoon Shariat
doaj  

Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B [PDF]

, 2014
Hepadnavirus at very low doses establishes in woodchucks asymptomatic, serologically undetectable but molecularly evident persistent infection. This primary occult infection (POI) preferentially engages the immune system and initiates virus-specific T ...
Chauhan, Ranjit
core   +1 more source

Prevalence of occult hepatitis B virus infection

World Journal of Gastroenterology, 2011
Occult hepatitis B virus (HBV) infection (OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface antigen. The prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world, the different assays utilized in the studies, and the different ...
Maria Luisa, Gutiérrez-García, Conrado M, Fernandez-Rodriguez, Jose Luis, Lledo-Navarro, Ingrid, Buhigas-Garcia   +3 more
openaire   +2 more sources

Distinct 5′ UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses

Microbiology and Immunology, Volume 70, Issue 2, Page 80-90, February 2026.
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Meng‐Chi Wu, Takehiro Kanda, Ryo Komorizono, Madoka Sakai, Alexander Leacy, Leonardo Susta, Akiko Makino, Keizo Tomonaga   +7 more
wiley   +1 more source

Booster immunity – diagnosis of chronic hepatitis B viral infection

Journal of Infection in Developing Countries, 2019
Introduction: Diagnosis of chronic hepatitis B virus (HBV) infection particularly its occult form requires monitoring and repeat serological and molecular studies.
Radka T Komitova, Ani K Kevorkyan, Maria V Atanasova, Aneta V Ivanova, Elica Golkocheva-Markova   +4 more
doaj   +1 more source

Occult hepatitis B virus and hepatocellular carcinoma

World Journal of Gastroenterology, 2014
Occult hepatitis B virus (HBV) infection (OBI) is a challenging pathobiological and clinical issue that has been widely debated for several decades. By definition, OBI is characterized by the persistence of HBV DNA in the liver tissue (and in some cases also in the serum) in the absence of circulating HBV surface antigen (HBsAg).
POLLICINO, Teresa, SAITTA, CARLO
openaire   +2 more sources

Exacerbation of Anti‐Cytomegalovirus Immunity and Mobilization of γ9δ1 T Cells During the Acute Phase of Hepatitis E Virus Infection

Microbiology and Immunology, Volume 70, Issue 2, Page 113-124, February 2026.
ABSTRACT HEV causes chronic infections that are detrimental to immunocompromised patients. Previous studies showed alterations of γδ T cell subsets at the acute phase of HEV infection. To assess a possible role of CMV, we have examined the frequencies and responses to CMV and HEV of blood γδ T cell subsets from control donors and acute‐phase HEV ...
Marion Retailleau, Fanny Martini, Florence Abravanel, Nassim Kamar, Jacques Izopet, Eric Champagne   +5 more
wiley   +1 more source

Hepatitis B virus reactivation in breast cancer patients undergoing chemotherapy: A review and meta-analysis of prophylaxis management [PDF]

, 2017
Hepatitis B virus (HBV) reactivation during or after chemotherapy in patients with breast cancer has become a remarkable clinical problem. Prophylactic nucleos(t)ide analogues (NAs) are recommended for patients with breast cancer who are hepatitis B ...
Gong, Chang, Jiang, L., Jiang, Wen, Liang, G., Liu, Z, Song, E., Zheng, Y   +6 more
core   +2 more sources

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source