Results 171 to 180 of about 69,318 (308)

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Unrecognized Transmission Risks of Occult Hepatitis B Virus Infection Among Blood Donors in Central Ethiopia. [PDF]

Can J Infect Dis Med Microbiol
Beykaso G, Agde ZD, Gebre S, Girma T.
europepmc   +1 more source

3D Printed PEDOT:PSS‐Based Lattice Pressure Sensors With Tunable Electromechanical Response

Advanced Materials Technologies, EarlyView.
poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS)‐based architected lattices are fabricated via single‐step Digital Light Processing (DLP) printing for tunable pressure sensing. Structural design variations allow precise control of sensitivity and range, while integrated conductivity eliminates post‐processing.
Ozan Karakaya, Naroa Lopez‐Larrea, Ali Veysel Tunc, Mikel Rincon‐Iglesias, Karin J. Chen, Katja Nau, Senentxu Lanceros‐Mendez, David Mecerreyes, Miryam Criado‐Gonzalez, Gerardo Hernandez‐Sosa   +9 more
wiley   +1 more source

Micro Elastofluidics for Tuneable Droplet Merging

Advanced Materials Technologies, EarlyView.
This technical paper provides a proof of concept of fully flexible and stretchable microfluidic technology for tuneable droplet mixing and merging. The phenomenon is justified through theoretical, numerical and experimental studies. ABSTRACT Droplet microfluidics enables precise handling of discrete fluid volumes at the microscale, with broad ...
Uditha Roshan, Amith Mudugamuwa, Xiaoyue Kang, Prabuddha De Saram, Fariba Malekpour Galogahi, Du Tuan Tran, Lingxi Ouyang, Jun Zhang, Nam‐Trung Nguyen   +8 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Detection of Occult Retinal Breaks Using Subretinal Dye in Recurrent Retinal Detachment Surgery. [PDF]

Turk J Ophthalmol
Sül S, Tamer Kaderli S, Osmanlı E, Kaderli A.   +3 more
europepmc   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Implications of occult hepatitis B infection for blood donor management: a five-year evaluation from Western Saudi Arabia. [PDF]

BMC Infect Dis
Tounsi WA, Noorsaeed S, Almars AI, Almramhi MM, Basri AM, Basabrain AA, Rokan A, Almansouri TS, Mokhtar SH, Hakami NY.   +9 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source