Results 71 to 80 of about 690,968 (361)

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Asthma and treatment with inhaled corticosteroids: associations with hospitalisations with pneumonia

BMC Pulmonary Medicine, 2019
Background Pneumonia is an important cause of morbidity and mortality. COPD patients using inhaled corticosteroids (ICS) have an increased risk of pneumonia, but less is known about whether ICS treatment in asthma also increases the risk of pneumonia ...
Emil Ekbom, Jennifer Quint, Linus Schöler, Andrei Malinovschi, Karl Franklin, Mathias Holm, Kjell Torén, Eva Lindberg, Deborah Jarvis, Christer Janson   +9 more
doaj   +1 more source

Screening tools for work-related asthma and their diagnostic accuracy: a systematic review

BMJ Open Respiratory Research
Introduction One in four cases of asthma in adults is caused or worsened by work (work-related asthma: WRA). Early detection of WRA could prevent poor health and employment outcomes, but clinical diagnosis is often missed or delayed.
Peymane Adab, Rachel E Jordan, Gareth I Walters, Christopher C Huntley, Ngamjit Kongsupon, Shiyao Li, Siwanon Rattanakanokchai, Samuel Wallbanks   +7 more
doaj   +1 more source

Silica exposure and work-relatedness evaluation for occupational cancer in Korea

Annals of Occupational and Environmental Medicine, 2018
Crystalline silica has been classified as a definite carcinogen (Group 1) causing lung cancer by the International Agency for Research on Cancer (IARC). In Korea, crystalline silica has been the most common causal agent for workers to apply to the Korea ...
Hyoung-Ryoul Kim, Boowook Kim, Bum Seak Jo, Ji-Won Lee   +3 more
doaj   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Reaction time and incident cancer: 25 years of follow-up of study members in the UK Health and Lifestyle Survey [PDF]

, 2014
<b>Objectives</b><p></p> To investigate the association of reaction time with cancer incidence.<p></p> <b>Methods</b><p></p> 6900 individuals aged 18 to 94 years who participated in the
B Secretan, BA Shipley, BA Shipley, Beverly A. Roberts, CL Hart, CL Hart, CM Calvin, CR Gale, Dominika Dykiert, E Whitley, G. David Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, GD Batty, Geoff Der, Ian J. Deary, IJ Deary, IJ Deary, NP Walker, Suminori Akiba, T Chandola, T Hemmingsson, T Hemmingsson   +30 more
core   +3 more sources

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Ambulatory oxygen in fibrotic lung disease (AmbOx): study protocol for a randomised controlled trial

Trials, 2017
Background Fibrotic interstitial lung diseases (ILDs) are chronic and often progressive conditions resulting in substantial morbidity and mortality. Shortness of breath, a symptom often linked to oxygen desaturation on exertion, is tightly linked to ...
Dina Visca, Vicky Tsipouri, Letizia Mori, Ashi Firouzi, Sharon Fleming, Morag Farquhar, Elizabeth Leung, Toby M. Maher, Paul Cullinan, Nick Hopkinson, Athol U. Wells, Winston Banya, Jennifer A. Whitty, Huzaifa Adamali, Lisa G. Spencer, Piersante Sestini, Elisabetta A. Renzoni   +16 more
doaj   +1 more source

Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden. [PDF]

, 2015
BACKGROUND: We have conducted a population-based study of pleural mesothelioma patients with occupational histories and measured asbestos lung burdens in occupationally exposed workers and in the general population.
Burdett, G, Carpenter, J, Darnton, A, Davison, L, Franchini, A, Gilham, C, Hodgson, J, Nicholson, AG, Peto, J, Rake, C   +9 more
core   +2 more sources

Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture

Advanced Science, EarlyView.
Inhaled NCM particles undergo lysosomal degradation, releasing complex ion mixtures that induce systemic impact. The impact is determined by a critical balance between antagonistic Ni‐Co interactions and synergistic Mn effects. To capture these complexities in risk assessment, we develop an IAI model, ensuring a more accurate quantitative risk ...
Ze Zhang, Gan Miao, Xueyu Zhang, Zhao Shu, Dawei Lu, Yujie Song, Shanfa Yu, Qian Liu, Yang Song, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source