In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Shades of grey : understanding job quality in emerging graduate occupations
This study examines job quality for university graduates employed in intermediately skilled (emerging) and traditional graduate occupations. Skills policies largely assume that increasing the supply of skilled labour generates sufficient demand in terms ...
Scholarios, Dora +1 more
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Tasks and Heterogeneous Human Capital [PDF]
This paper proposes a new approach to modeling heterogeneous human capital using task data from the Dictionary of Occupational Titles. The key feature of the model is that it departs from the Roy model, which treats occupations as distinct categories ...
Shintaro Yamaguchi
core
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
A Pollution Theory of Discrimination: Male and Female Differences in Occupations and Earnings [PDF]
Occupations are segregated by sex today, but were far more segregated in the early to mid-twentieth century when married women began to enter the labor force in large numbers.
Claudia Goldin
core
Sex-Typing of Tasks and Occupations
A Task Index and an Occupations Index were each generated in a three-step process including general solicitation of tasks and occupations, solicitation of specific tasks and occupations, solicitation of specific tasks and occupations associated with one
William E. Walker, Mary F. Chewning
core +1 more source
Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
How Asian Americans Fare in the Labor Market: The Intersection of Education, Gender, and Ethnicity
Studies of Asian Americans in the labor market point to significant variations in experiences by educational attainment, gender, and ethnicity, but few studies attend to the intersections of these characteristics in yielding disparate patterns of ...
Phoebe Ho, Hyunjoon Park
doaj +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source

