Results 11 to 20 of about 94 (93)

Residual flexibility in the topologically constrained multivalent complex between the GKAP scaffold and LC8 hub proteins

The FEBS Journal, Volume 293, Issue 1, Page 76-95, January 2026.
The scaffold protein GKAP and the hub protein LC8 form a well‐defined hexameric complex, with the stoichiometry of 2 GKAP : 2 LC8 dimers. NMR and molecular dynamics calculations confirm that the LC8‐binding segment of GKAP is intrinsically disordered even in the complex form.
Eszter Nagy‐Kanta, Zsófia E. Kálmán, Helena Tossavainen, Tünde Juhász, Fanni Farkas, József Hegedüs, Melinda Keresztes, Tamás Beke‐Somfai, Zoltán Gáspári, Perttu Permi, Bálint Péterfia   +10 more
wiley   +1 more source

The GFDL‐CM4X Climate Model Hierarchy, Part I: Model Description and Thermal Properties

Journal of Advances in Modeling Earth Systems, Volume 17, Issue 10, October 2025.
Abstract We present the GFDL‐CM4X (Geophysical Fluid Dynamics Laboratory Climate Model version 4X) coupled climate model hierarchy. The primary application for CM4X is to investigate ocean and sea ice physics as part of a realistic coupled Earth climate model.
Stephen M. Griffies, Alistair Adcroft, Rebecca L. Beadling, Mitchell Bushuk, Chiung‐Yin Chang, Henri F. Drake, Raphael Dussin, Robert W. Hallberg, William J. Hurlin, Hemant Khatri, John P. Krasting, Matthew Lobo, Graeme A. MacGilchrist, Brandon G. Reichl, Aakash Sane, Olga Sergienko, Maike Sonnewald, Jacob M. Steinberg, Jan‐Erik Tesdal, Matthew Thomas, Katherine E. Turner, Marshall L. Ward, Michael Winton, Niki Zadeh, Laure Zanna, Rong Zhang, Wenda Zhang, Ming Zhao   +27 more
wiley   +1 more source

Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib

British Journal of Pharmacology, Volume 182, Issue 19, Page 4668-4692, October 2025.
Background and Purpose Hidden cardiotoxicity is defined as drug‐induced cardiotoxicity that becomes obvious only in the presence of comorbidities. However, the molecular mechanisms of hidden cardiotoxicity are not always known. Therefore, unbiased multi‐omics approaches could assist in revealing regulatory pathways.
Bennet Y. Weber, Gábor B. Brenner, Barnabás Váradi, Bence Ágg, Csenger Kovácsházi, Olivér M. Balogh, Donagh Egan, Kieran Wynne, David Matallanas, Rainer Schulz, Péter Ferdinandy, Zoltán Giricz, Anikó Görbe   +12 more
wiley   +1 more source

Genetic Adaptation to Brackish Water and Spawning Season in European Cisco

Molecular Ecology, Volume 34, Issue 20, October 2025.
ABSTRACT How species adapt to diverse environmental conditions is essential for understanding evolution and the maintenance of biodiversity. The European cisco (Coregonus albula) is a salmonid that occurs in both fresh and brackish water, and this together with the presence of sympatric spring‐ and autumn‐spawning lacustrine populations provides an ...
Qiaoling Deng, Jake Goodall, Mikaela Bergenius Nord, Ignas Bunikis, Arianna Cocco, Bo Delling, Elisabet Einarsdottir, Julia Heintz, Henrik Lantz, Kerstin Lindblad‐Toh, Mai‐Britt Mosbech, Remi‐Andre Olsen, Stefan Palm, Mats E. Pettersson, Martin Pippel, Lucile Soler, Anti Vasemägi, Olga Vinnere Pettersson, Leif Andersson   +18 more
wiley   +1 more source

Advancing Global Pulse Protein Production: Harnessing Emerging Technologies for Sustainable Cultivation and Fractionation of High‐Protein Pulse Crops

Sustainable Food Proteins, Volume 3, Issue 3, September 2025.
Advanced tools for enhancing pulse cultivation and protein processing. ABSTRACT Digital transformation is driving more precise, efficient, and sustainable practices in both farming and postharvest crop processing. As consumer preferences shift toward healthier alternative protein sources, pulses are gaining attention with their market currently valued ...
Rania Marie Buenavista, Snehasis Chakraborty, Kaliramesh Siliveru   +2 more
wiley   +1 more source

Self‐Supervised Coherence‐Based Denoising of Cryoseismological Distributed Acoustic Sensing Data

Journal of Geophysical Research: Machine Learning and Computation, Volume 2, Issue 3, September 2025.
Abstract A major challenge in cryoseismology is that signals of interest are often buried within the high noise level emitted by a variety of environmental processes. Particular Distributed Acoustic Sensing (DAS) data often suffers from low signal‐to‐noise ratios (SNR) potentially resulting in a multitude of undetected events of interest, which further
Johanna Zitt, Patrick Paitz, Andreas Fichtner, Fabian Walter, Josefine Umlauft   +4 more
wiley   +1 more source

Australian continental‐scale heavy mineral patterns track climate, weathering and erosion

Sedimentology, Volume 72, Issue 5, Page 1430-1452, August 2025.
ABSTRACT The heavy mineral cargo of sediment is influenced by a complex and variable overprint of climate and environmental processes acting on weathered crystalline basement sources. Here, a continental‐scale heavy mineral compositional dataset of 1315 surface sediment samples, analysed via automated mineralogy, from across Australia is utilized to ...
Maximilian Dröllner, Milo Barham, Christopher L. Kirkland, Andreas Zametzer, Maike Schulz   +4 more
wiley   +1 more source

Adjoint‐Based Online Learning of Two‐Layer Quasi‐Geostrophic Baroclinic Turbulence

Journal of Advances in Modeling Earth Systems, Volume 17, Issue 7, July 2025.
Abstract For reasons of computational constraint, most global ocean circulation models used for Earth System Modeling still rely on parameterizations of sub‐grid processes, and limitations in these parameterizations affect the modeled ocean circulation and impact on predictive skill.
F. E. Yan, H. Frezat, J. Le Sommer, J. Mak, K. Otness   +4 more
wiley   +1 more source

Characterizing Fractured Zones in Urban Karst Geology Using Leaky Surface Waves From Distributed Acoustic Sensing

Journal of Geophysical Research: Solid Earth, Volume 130, Issue 7, July 2025.
Abstract Urban karst geology poses significant geohazard risks, most notably sinkholes and surface depression stemming from soluble and fractured bedrock that is prone to dissolution and collapse. However, mapping and characterizing these hazards using traditional geophysical surveys in cities is challenging due to dense infrastructure and high levels ...
Zhinong Wang, Tieyuan Zhu
wiley   +1 more source

Ultrasound fundamentals and their clinical implications for interventional cytopathologists

Cytopathology, Volume 36, Issue 4, Page 356-374, July 2025.
Interventional cytopathologists need to know about ultrasound physics and instrumentation to produce an image that faithfully recreates the lesion discovered by the sonographer and diagnosed by the radiologist. A deep quantitative understanding of physics is not required.
David Lieu
wiley   +1 more source