Results 11 to 20 of about 10,829 (144)

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo. [PDF]

Adv Sci (Weinh)
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Li M, Lyu J, Li K, Dravid A, Balasubramani D, K Ashkezari AH, Choi HK, Kwong GA, Singh A, Zhu C.   +9 more
europepmc   +2 more sources

IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. [PDF]

Adv Sci (Weinh)
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Cui Y, Sun Y, Liu Z, Lai X, Zhao Y, Wang Y, He Y, Xu F, Feng D, Liu L, Huang Z, Xing L, Mao X.   +12 more
europepmc   +2 more sources

Nucleolin Alterations and ROS Production Associate With Sensitivity of AML Cells to Venetoclax. [PDF]

FASEB J
Venetoclax‐induced Bcl‐2 inhibition corresponds with Mcl‐1 attenuation and decrease of Nucleolin (NCL) level and activity in sensitive cells. Simultaneously, distinct cell subpopulations with opposite mitochondrial (CellROX label, magenta) and cellular (H2DCFDA stain, green) ROS occur, and the H2DCFDA‐positive population shows markers of early ...
Wolfová K, Otevřelová P, Brodská B.
europepmc   +2 more sources

Re-thinking breast and cervical cancer preventive campaigns in developing countries: the case for interventions at high schools

BMC Public Health, 2019
Background The negative impact of cervical and breast cancers in low and lower-middle income countries are worsening, and, along with other non-communicable diseases, occur disproportionately in these resource-limited economies.
Chris Onyebuchi Ifediora
doaj   +1 more source

Prevalence and follow-up of occult HCV infection in an Italian population free of clinically detectable infectious liver disease. [PDF]

PLoS ONE, 2012
BACKGROUND: Occult hepatitis C virus infection (OCI) is a recently described phenomenon characterized by undetectable levels of HCV-RNA in serum/plasma by current laboratory assays, with identifiable levels in peripheral blood mononuclear cells (PBMCs ...
Laura De Marco, Paola Manzini, Morena Trevisan, Anna Gillio-Tos, Franca Danielle, Cinzia Balloco, Alessandra Pizzi, Eleonora De Filippo, Sergio D'Antico, Beatrice Violante, Adriano Valfrè, Franco Curti, Franco Merletti, Lorenzo Richiardi   +13 more
doaj   +1 more source

Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New Vision

Diagnostics, 2022
Occult hepatitis C virus infection (OCI) is the absence of HCV RNA in serum and the presence of actively replicating HCV RNA in hepatocytes and peripheral blood mononuclear cells (PBMCs), as evidenced by the presence of antigenomic negative sense single ...
Kholoud A. Elkashef, Wafaa A. Emam, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed   +4 more
doaj   +1 more source

Turisme, tecnologia i narratives: reflexions per al disseny d'espais turístics

Temes de Disseny, 2019
Caracteritzem el turisme essencialment com un fenomen comunicatiu entre una arquitectura, un territori, un espai i els seus visitants. El disseny d'espais turístics ha evolucionat al llarg del temps segons les tecnolgies emprades per construir-los.
Rafael de Villasante García, Sílvia Casellas Oriol   +1 more
doaj   +4 more sources

Electroencephalographic Findings in Idiopathic Rapid Eye Movement Sleep Behavior Disorder with Objective Cognitive Impairment [PDF]

Sleep Medicine Research, 2021
Background and Objective Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at the risk of developing neurodegenerative disorders including mild cognitive impairment (MCI).
Jeehyun Hyun, Jung Kyung Hong, In-Young Yoon   +2 more
doaj   +1 more source

Escola, oci i joves d’origen magribí. Segones generacions de famílies immigrades i el sentit de la seva inserció social. El cas de Mataró

Papers, 2002
Aquest article és fruit de la ponència presentada al III Congrés Català de Sociologia (Lleida, 20 i 21 de març de 1999), arran de la investigació realitzada sota el mateix títol al municipi de Mataró i finançada per la Fundació Jaume Bofill. El text aquí
Miquel Àngel Alegre Canosa, Diego Herrera Aragón   +1 more
doaj   +1 more source

Epidemiology of occult hepatitis B and C in Africa: A systematic review and meta-analysis

Journal of Infection and Public Health, 2022
Background: Occult hepatitis B (OBI) and C (OCI) infections lead to hepatic crises including cases of liver cirrhosis and even hepatocellular carcinoma (HCC). OBI and OCI also pose a significant problem of their transmissibility.
Juliette Laure Ndzie Ondigui, Sebastien Kenmoe, Cyprien Kengne-Ndé, Jean Thierry Ebogo-Belobo, Guy Roussel Takuissu, Raoul Kenfack-Momo, Donatien Serge Mbaga, Serges Tchatchouang, Josiane Kenfack-Zanguim, Robertine Lontuo Fogang, Elisabeth Zeuko'o Menkem, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Arnol Bowo-Ngandji, Nadège Mafopa Goumkwa, Seraphine Nkie Esemu, Lucy Ndip, Sara Honorine Riwom Essama, Judith Torimiro   +18 more
doaj   +1 more source