Results 111 to 120 of about 33,894 (216)

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Setting the Record Straight: The Intellectual Legacy of H. Igor Ansoff (1918–2002)

Strategic Change, EarlyView.
ABSTRACT This study presents a comprehensive annotated bibliography of H. Igor Ansoff's intellectual contributions, addressing significant gaps in existing citation databases such as Scopus and Web of Science, which capture only 9 to 15 percent of his work.
Richard W. Puyt
wiley   +1 more source

Universal Risk Stratification in Stage I–III Cutaneous Melanoma Using 31‐gene Expression Profiling: A Single‐Center Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Patients with early‐stage cutaneous melanoma (CM) have low individual risk but account for most distant recurrences. The utility of gene expression profiling (GEP) in CM risk stratification and clinical management remains unclear. Methods From 2015 to 2022, CM patients at a single center were universally referred for DecisionDx 31 ...
Daniel B. Gehle, Philip W. Morgan, Emme M. Fitts, Nathaniel L. Hauser, Chelsea R. Olson, Andrew M. Fleming, Julia Pedo Freitas, Feng Liu‐Smith, Simonne S. Nouer, Andrew J. Murphy, Martin D. Fleming   +10 more
wiley   +1 more source

Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate. [PDF]

Sci Rep
Ransy C, Boissan M, Hammad N, Bouaboud A, Issad T, De Dieuleveult M, Miotto B, Ye M, Pasmant E, Bouillaud F.   +9 more
europepmc   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

Bt agave: why it is time to explore a new biotechnological frontier

Pest Management Science, EarlyView.
Drylands cover 41% of Earth, requiring sustainable crops. Agave, drought‐ and heat‐adapted, offers high‐value products with low water needs. Pests limit yield, yet Bacillus thuringiensis (Bt) Cry proteins, successful in other plants, remain unexploited in Agave.
Aline Vitória Corim Marim, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira, Carolina Rossi De Oliveira   +3 more
wiley   +1 more source

Short-term effects of ocrelizumab on cortical pathology in patients with multiple sclerosis. [PDF]

Neurotherapeutics
Cavalli N, Boffa G, Cipriano E, Boccia VD, Al Qudsi S, Baldisseri F, Leveraro E, Nasone L, Magon S, Cellerino M, Inglese M, Lapucci C.   +11 more
europepmc   +1 more source

Integrating multimodal data and machine learning for entrepreneurship research

Strategic Entrepreneurship Journal, EarlyView.
Abstract Research Summary Extant research in neuroscience suggests that human perception is multimodal in nature—we model the world integrating diverse data sources such as sound, images, taste, and smell. Working in a dynamic environment, entrepreneurs are expected to draw on multimodal inputs in their decision making.
Yash Raj Shrestha, Vivianna Fang He
wiley   +1 more source

Patient-derived glioblastoma cultures preserve respiration phenotypes during ex vivo maintenance and show sex-associated differences in migration. [PDF]

Acta Neuropathol Commun
Matschke V, Glover P, Lucaciu R, Pickmann D, Scholz M, Theiss C, Hoffmann D, Matschke J.   +7 more
europepmc   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source