Results 21 to 30 of about 455,543 (293)

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an in vitro model for assessing population variability in hepatotoxicity testing

Current Research in Toxicology
Interindividual differences in response to chemicals have been typically addressed through the use of a 10-fold default “uncertainty” factor. It was only recently that in vitro models emerged to quantitatively assess interindividual variability in the ...
Xiugong Gao, Rong Li, Kayla Campasino, Miranda R. Yourick, Yang Zhao, Robert L. Sprando, Jeffrey J. Yourick   +6 more
doaj   +1 more source

Inflow mapping method for numerical flow simulations of OCT-based patient-specific vessels using CFD

Current Directions in Biomedical Engineering, 2017
Alteration of the flow characteristics in coronary vessels is correlated with coronary heart disease (CHD). In particular, wall shear stress (WSS) appears to be a hemody-namic key factor in the genesis of CHD.
Wüstenhagen Carolin, Borowski Finja, Haude Michael, Neumann Franz-Josef, Grabow Niels, Schmitz Klaus-Peter, Stiehm Michael   +6 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Optical Coherence Tomography Can Predict Visual Acuity in Children with Optic Nerve Hypoplasia

Clinical Ophthalmology, 2022
Athanasia Skriapa-Manta,1,2 Mattias Nilsson,1 Jan Svoboda,3 Monica Olsson,1,2 Maria Nilsson,4 Kristina Teär Fahnehjelm1,2 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Department of Paediatric Ophthalmology, Strabismus ...
Skriapa-Manta A, Nilsson M, Svoboda J, Olsson M, Nilsson M, Teär Fahnehjelm K   +5 more
doaj  

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

Computed Tomography Biomarkers of Vulnerable Coronary Plaques

Journal of Interdisciplinary Medicine, 2016
An unstable plaque has a high risk of thrombosis and at the same time for a fast progression of the stenosis degree. Also, “high-risk plaque” and “thrombosis-prone plaque” are used as synonym terms for characterization of a vulnerable plaque. The imaging
Nyulas Tiberiu, Chiţu Monica, Mester András, Jáni Laura, Condrea Sebastian, Opincariu Diana, Kovács István, Benedek Imre, Benedek Theodora   +8 more
doaj   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

An updated comparison of microarray and RNA-seq for concentration response transcriptomic study: case studies with two cannabinoids, cannabichromene and cannabinol

BMC Genomics
Background Transcriptomic benchmark concentration (BMC) modeling provides quantitative toxicogenomic information that is increasingly being used in regulatory risk assessment of data poor chemicals.
Xiugong Gao, Miranda R. Yourick, Kayla Campasino, Yang Zhao, Estatira Sepehr, Cory Vaught, Robert L. Sprando, Jeffrey J. Yourick   +7 more
doaj   +1 more source

Non-Invasive Diagnosis of Polypoidal Choroidal Vasculopathy as a Variant of the Course of Age-Related Macular Degeneration

Oftalʹmologiâ, 2018
Purpose: to study noninvasive diagnostic options for polypoidal choroidal vasculopathy (PCV) — a subtype of neovascular agerelated macular degeneration — by monitoring clinical progression, defining optical coherence tomography (OCT) findings specific ...
I. E. Panova, T. B. Shaimov, V. A. Shaimova   +2 more
doaj   +1 more source