Results 41 to 50 of about 511,069 (264)

Non-Invasive Diagnosis of Polypoidal Choroidal Vasculopathy as a Variant of the Course of Age-Related Macular Degeneration

Oftalʹmologiâ, 2018
Purpose: to study noninvasive diagnostic options for polypoidal choroidal vasculopathy (PCV) — a subtype of neovascular agerelated macular degeneration — by monitoring clinical progression, defining optical coherence tomography (OCT) findings specific ...
I. E. Panova, T. B. Shaimov, V. A. Shaimova   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An updated comparison of microarray and RNA-seq for concentration response transcriptomic study: case studies with two cannabinoids, cannabichromene and cannabinol

BMC Genomics
Background Transcriptomic benchmark concentration (BMC) modeling provides quantitative toxicogenomic information that is increasingly being used in regulatory risk assessment of data poor chemicals.
Xiugong Gao, Miranda R. Yourick, Kayla Campasino, Yang Zhao, Estatira Sepehr, Cory Vaught, Robert L. Sprando, Jeffrey J. Yourick   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

CLINICAL STUDY REPORT: AN OVERVIEW OF REGULATORY DOCUMENTS AND THE ORGANIZATIONAL AND PRACTICAL ASPECTS OF DEVELOPMENT

Разработка и регистрация лекарственных средств, 2019
Clinical study report is one of the main documents during the drug development. The preparation of the clinical study report requires knowledge of Russian and foreign legislation, awareness of guidelines and recommendatioins issued by the professional ...
E. A. Radkova, I. N. Petrova, K. A. Leus, I. A. Dobromyslov   +3 more
doaj  

Evaluation of optical coherence tomography changes in amblyopia

Indian Journal of Ophthalmology
Aim: To study the Central Macular Thickness (CMT) and Retinal nerve fiber layer (RNFL) thickness (RNFLT) using Optical Coherence Tomography (OCT) in cases of amblyopia.
Jawahar L Goyal, Jigyasa Arora, Abha Gahlot, Divya Singh, Neharika Sharma, Nisha Yadav   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Retinal revelations: Seeing beyond the eye with artificial intelligence

Kerala Journal of Ophthalmology
Artificial intelligence (AI) has revolutionized ophthalmology by aiding in the diagnosis, prognosis, and treatment planning of various eye diseases. However, AI’s potential extends beyond ocular conditions.
John Davis Akkara
doaj   +1 more source

Regarding the Use of Direct-Acting Anticoagulants of Animal Origin in Diabetic Retinopathy

Oftalʹmologiâ, 2023
Relevance. Diabetic retinopathy occupies one of the leading places in the frame of blindness and low vision. The very first changes in the retina in diabetic retinopathy are disorders of microcirculation and blood supply in the small vessels of the ...
I. V. Vorobyeva, V. V. Biryukov, M. A. Frolov, A. M. Frolov, U. S. Pliaskina, S. Shallah   +5 more
doaj   +1 more source