Results 61 to 70 of about 2,729,861 (305)

An updated comparison of microarray and RNA-seq for concentration response transcriptomic study: case studies with two cannabinoids, cannabichromene and cannabinol

open access: yesBMC Genomics
Background Transcriptomic benchmark concentration (BMC) modeling provides quantitative toxicogenomic information that is increasingly being used in regulatory risk assessment of data poor chemicals.
Xiugong Gao   +7 more
doaj   +1 more source

Regarding the Use of Direct-Acting Anticoagulants of Animal Origin in Diabetic Retinopathy

open access: yesOftalʹmologiâ, 2023
Relevance. Diabetic retinopathy occupies one of the leading places in the frame of blindness and low vision. The very first changes in the retina in diabetic retinopathy are disorders of microcirculation and blood supply in the small vessels of the ...
I. V. Vorobyeva   +5 more
doaj   +1 more source

Optical coherence tomography and scanning laser ophthalmoscopy: Approaches to dual-channel retinal tissue imaging [PDF]

open access: yes, 2014
We report a Talbot bands-based optical coherence tomography (OCT) system capable of producing longitudinal B-scan OCT images and en-face scanning laser ophthalmoscopy (SLO) images of the human retina in-vivo, with various degrees of ...
Marques, Podoleanu, Potsaid, Wojtkowski
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

CLINICAL STUDY REPORT: AN OVERVIEW OF REGULATORY DOCUMENTS AND THE ORGANIZATIONAL AND PRACTICAL ASPECTS OF DEVELOPMENT

open access: yesРазработка и регистрация лекарственных средств, 2019
Clinical study report is one of the main documents during the drug development. The preparation of the clinical study report requires knowledge of Russian and foreign legislation, awareness of guidelines and recommendatioins issued by the professional ...
E. A. Radkova   +3 more
doaj  

Evaluation of optical coherence tomography changes in amblyopia

open access: yesIndian Journal of Ophthalmology
Aim: To study the Central Macular Thickness (CMT) and Retinal nerve fiber layer (RNFL) thickness (RNFLT) using Optical Coherence Tomography (OCT) in cases of amblyopia.
Jawahar L Goyal   +5 more
doaj   +1 more source

Optical coherence tomography and microperimetry in the early diagnosis of glaucoma

open access: yesРоссийский офтальмологический журнал, 2022
The review presents modern possibilities of early diagnosis of glaucoma using optical coherence tomography (OCT), angio-OCT and microperimetry. We analyzed literature data for the last decade, focused on testing patients with suspected glaucoma or ...
U. S. Plyaskina   +2 more
doaj   +1 more source

Pump-probe scheme for optical coherence tomography using indocyanine green mixed with albumin or human plasma [PDF]

open access: yes, 2005
Use of indocyanine green (ICG) in a pump-probe scheme for OCT is proposed. The study illustrates that ICG in protein solution shows unusual pump-probe imaging potential, indicating its usefulness as a contrast agent for ...
Applegate, Brian E.   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Ultra-high resolution Fourier domain optical coherence tomography for resolving thin layers in painted works of art [PDF]

open access: yes, 2013
While OCT has been applied to the non-invasive examination of the stratigraphy of paint layers in recent years, it has been recognized that the resolutions of commercially available OCT cannot compete in depth resolution with conventional microscopic ...
Cheung, CS, Liang, H
core   +1 more source

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