Results 31 to 40 of about 455,543 (293)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 Clinical study report is one of the main documents during the drug development. The preparation of the clinical study report requires knowledge of Russian and foreign legislation, awareness of guidelines and recommendatioins issued by the professional ...
E. A. Radkova +3 more
doaj
Evaluation of optical coherence tomography changes in amblyopia
Indian Journal of OphthalmologyAim: To study the Central Macular Thickness (CMT) and Retinal nerve fiber layer (RNFL) thickness (RNFLT) using Optical Coherence Tomography (OCT) in cases of amblyopia.
Jawahar L Goyal +5 more
doaj +1 more source
Regarding the Use of Direct-Acting Anticoagulants of Animal Origin in Diabetic Retinopathy
Oftalʹmologiâ, 2023 Relevance. Diabetic retinopathy occupies one of the leading places in the frame of blindness and low vision. The very first changes in the retina in diabetic retinopathy are disorders of microcirculation and blood supply in the small vessels of the ...
I. V. Vorobyeva +5 more
doaj +1 more source
Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2 [PDF]
Nucleic Acids Research, 1993 Members of the Oct family of transcription factors specifically interact with the octamer motif, ATGC-AAAT, a regulatory element important for tissue- and cell-specific transcription as well as for the expression of housekeeping genes. Except for Oct-1, all Oct factors are expressed in a temporally and spatially restricted mode during murine ...
Suzuki, N. +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Optical coherence tomography and microperimetry in the early diagnosis of glaucoma
Российский офтальмологический журнал, 2022 The review presents modern possibilities of early diagnosis of glaucoma using optical coherence tomography (OCT), angio-OCT and microperimetry. We analyzed literature data for the last decade, focused on testing patients with suspected glaucoma or ...
U. S. Plyaskina +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Retinal revelations: Seeing beyond the eye with artificial intelligence
Kerala Journal of OphthalmologyArtificial intelligence (AI) has revolutionized ophthalmology by aiding in the diagnosis, prognosis, and treatment planning of various eye diseases. However, AI’s potential extends beyond ocular conditions.
John Davis Akkara
doaj +1 more source
MEMS-VCSEL as a tunable light source for OCT imaging of long working distance [PDF]
, 2021 Mohammed S. Khan +5 more
openalex +1 more source