Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research [PDF]
Frontiers in Aging NeuroscienceThe Chilean degu (Octodon degus) is a medium sized, long-lived rodent with traits that make them a natural model for neuroscience research. Their social behaviors, diurnality, and extended developmental time course, when compared to other rodents, make ...
B. Maximiliano Garduño +8 more
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Familiarity and social relationships in degus (<i>Octodon degus</i>). [PDF]
EthologyAs strangers become more familiar (“exposures,” x‐axis), interaction levels (y‐axis) are expected to become more similar to those of long‐term cagemates. In males, this was the case (triangular, blue shading) with hints of established dominance. Some females interacted more with strangers (SC‐HIGH, solid red), and some not (SC‐LOW, dashed red), though ...
Thatcher A, Insel N.
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Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus) [PDF]
Veterinary Sciences, 2020 In recent years, degus (Octodon degus), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports.
Tanja Švara +4 more
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Effects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze task [PDF]
Frontiers in Behavioral Neuroscience, 2023 IntroductionProlonged social isolation is a form of passive chronic stress that has consequences on human and animal behavior. The present study was undertaken to elucidate whether the long-term isolation would precipitate age-related changes in anxiety ...
Natalija Popović +12 more
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Light color importance for circadian entrainment in a diurnal (Octodon degus) and a nocturnal (Rattus norvegicus) rodent [PDF]
Scientific Reports, 2017 The central circadian pacemaker (Suprachiasmatic Nuclei, SCN) maintains the phase relationship with the external world thanks to the light/dark cycle. Light intensity, spectra, and timing are important for SCN synchronisation.
Maria Angeles Bonmati-Carrion +3 more
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Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease [PDF]
Scientific Reports, 2022 The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD).
Matias Mugnaini +7 more
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Differential Role of Sex and Age in the Synaptic Transmission of Degus (Octodon degus) [PDF]
Frontiers in Integrative Neuroscience, 2022 Octodon degus are a diurnal long-lived social animal widely used to perform longitudinal studies and complex cognitive tasks to test for physiological conditions with similitude in human behavior.
Carolina A. Oliva +5 more
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Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease [PDF]
Acta Neuropathologica Communications, 2022 The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD.
Zhiqun Tan +7 more
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Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease [PDF]
Frontiers in Integrative Neuroscience, 2021 Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia. Although transgenic Alzheimer's disease (AD) animal models have greatly contributed to our understanding of the disease, therapies tested in these ...
Pedro Cisternas +4 more
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Octodon Degus: A Strong Attractor for Alzheimer Research [PDF]
Basic and Clinical Neuroscience, 2013 The most popular animal models of Alzheimer’s disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease.
Rafael Castro-Fuentes +1 more
doaj +5 more sources