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Developmental Toxicity Evaluation of Rats Dosed Orally or Cutaneously With Octoxynol-9
Journal of Applied Toxicology, 1999Pregnant CD rats were dosed cutaneously (530, 1600 or 4270 mg kg-1 day-1) or fed diets containing octoxynol-9 (70 or 340 mg kg-1 day-1) during the major period of organogenesis. Monitors for maternal toxicity included clinical observations, body weight, organ weight and food consumption. Fetuses were evaluated for body weight and for external, visceral
Bryan Ballantyne, B Ballantyne
exaly +5 more sources
Immunotoxicology Studies on Octoxynol-9 and Nonoxynol-9 in Mice
Toxicology Letters, 1987In a double-blind study, mice were injected intraperitoneally with 0.2 ml 0.2% octoxynol-9 (O-9), 0.2 ml 0.2% nonoxynol-9 (N-9), or 0.2 ml saline (control) daily for 24 days. Another control group received no treatment. All mice were immunized twice with sheep red blood cells (SRBC) and bled by caudal incision.
L D, Caren, V, Brunmeier
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Evaluation of the Cytotoxicity and Genotoxicity of the Spermicides Nonoxynol-9 and Octoxynol-9
Toxicology Letters, 1986The cytotoxic and genotoxic potentials of the spermicidal agents, nonoxynol-9 (N-9) and octoxynol-9 (0-9), were evaluated in in vitro test systems using rat liver cells. N-9 was also tested for the induction of sperm abnormalities in mice. Dose-related cytocidal effects were seen after the addition of N-9 and O-9 to the culture medium for 24 h.
H S Buttar
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Journal of Colloid and Interface Science, 1998
The surface-chemical properties, critical micelle concentrations (CMC), and effect of salts on the cloud points (CP) of octoxynol 9 (Triton X-100) and tyloxapol (Triton WR-1339) were compared. The latter nonionic surfactant is essentially a heptamer of the former. Even though the molecular weight of tyloxapol is 7 times larger than that of octoxynol 9,
Hans Schott
exaly +3 more sources
The surface-chemical properties, critical micelle concentrations (CMC), and effect of salts on the cloud points (CP) of octoxynol 9 (Triton X-100) and tyloxapol (Triton WR-1339) were compared. The latter nonionic surfactant is essentially a heptamer of the former. Even though the molecular weight of tyloxapol is 7 times larger than that of octoxynol 9,
Hans Schott
exaly +3 more sources