Results 81 to 90 of about 336,794 (287)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evaluation of Ocular Complications in Intraoral Local Anesthesia

Journal of Pharmacy and Bioallied Sciences
Background: The most significant medications in dentistry are local anesthetics, and intraoral local anesthesia is arguably the most used dental procedure. However, complications have also been reported.
Rameet Sandhu, Vikas Sikarwar, Sushil Ojha, Dushyant Upadhyay, Anshdeep Singh, Shweta Sharma   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

New type of perceptual suppression during dynamic ocular accommodation

, 2008
SummaryWhen viewing natural scenes saccadic eye movements are used to position retinal images of interest on the fovea, while vergence eye movements act to minimise retinal disparity and maintain a single binocular view of the target.
Mucke, Sven, Gray, Lyle S., Seidel, Dirk, Strang, Niall C.; id_orcid, Manahilov, Velitchko   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

[Effect of noise on ocular accommodation].

Klinika oczna, 1991
The goal of investigations was the determination of connection between the level of noise and the extra-auditory reaction of the organism--a change of the near point. Changes of accommodation determined by means of a black-and-white check-board test were monitored in the course and after 1 hour exposition to noise of 90 dB-A, 93 dB-A, 96 dB-A or 99 dB ...
openaire   +2 more sources

Arterial pulse modulates steady-state ocular accommodation

, 1990
Rapid and continuous fluctuations in ocular focus are known to occur when the eye views a stationary target. The advent of high-speed infra-red optometers has established that these microfluctuations of ocular accommodation have two dominant components ...
Owens, H., Winn, B., Pugh, J. R., Gilmartin, B.   +3 more
core   +1 more source

Epidemiological study of ocular trauma in an urban slum population in Delhi, India. [PDF]

, 2008
PURPOSE: To study the epidemiology and clinical profile of victims of ocular trauma in an urban slum population. MATERIALS AND METHODS: This cross-sectional study, conducted on 500 families each in three randomly selected urban slums in Delhi, collected ...
Vats, S, Gupta, SK, Vashist, P, Chandra, M, Gogoi, M, Murthy, GVS   +5 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Accommodation stimulus-response function and retinal image quality [PDF]

, 2006
Accommodation stimulus–response function (ASRF) and its relationship to retinal image quality were investigated using a modified wavefront sensor. Ten subjects were presented with six vergence stimuli between 0.17D and 5D.
Buehren, Tobias F., Collins, Michael J.
core   +1 more source