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The structural basis of the blood-ocular barriers
Experimental Eye Research, 1977In the mammalian eye, endothelial barriers are localized in the vessels of (i) the retina, (ii) optic nerve, (iii) ciliary muscle and (iv) iris. The endothelial barrier of the vessels in the retina is insensitive to drugs or autocoids, whereas the vessels of the iris may respond to pharmacological manipulations with increased permeability.
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Blood-ocular barrier damage: use of contrast-enhanced MRI
European Radiology, 1997The blood-ocular barrier (BOB) shares similar neuroepithelial origin, microanatomy and functions with the blood-brain barrier. There are many natural (e. g. diabetes, hypertension) or iatrogenic (chemotherapy, retinal photocoagulation) conditions which can cause a BOB breakdown, resulting in visual acuity impairment or loss.
L, Manfré +7 more
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Target strategies for drug delivery bypassing ocular barriers
Journal of Drug Delivery Science and Technology, 2020Abstract The eye is a directly accessible sensitive organ, impairment of which causes direct effect on the quality of life. Efficient ocular drug delivery remains a major challenge for the pharmaceutical scientists and researchers worldwide due to the hindrance offered by the complex ophthalmic environment, i.e., static barriers (stratified corneal ...
Reshal Suri, Sarwar Beg, Kanchan Kohli
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Ocular novel drug delivery: impacts of membranes and barriers
Expert Opinion on Drug Delivery, 2008Ocular drug delivery is an extremely challenging area due to its restrictive barrier functionalities.Drug transport via corneal/non-corneal routes involves several intricate biological processes such as drug penetration across the ocular barriers and transfer to the anterior or posterior chambers, thus the influence of these processes on the ...
Jaleh, Barar +2 more
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Antihistamines reverse blood-ocular barrier breakdown in experimental diabetes
Journal of Diabetic Complications, 1988Retinal and other tissue histamine synthesis is increased in experimental diabetes; histamine infusion causes blood-ocular barrier breakdown in nondiabetic rats. We have examined the hypothesis that antihistamines prevent blood-ocular barrier breakdown in streptozotocin diabetes using male Sprague-Dawley rats held 28 days.
T M, Hollis +7 more
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The blood-ocular barriers: past, present, and future
Documenta Ophthalmologica, 1997The blood-ocular barriers system is formed by two main barriers: the blood-aqueous barrier and the blood-retinal barrier. They combine to maintain the eye as a privileged site and are essential for normal visual function. After reviewing where the blood-aqueous barrier and blood-retinal barrier are located and the main transport mechanisms involved in ...
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Glucose transport across ocular barriers of the streptozotocin-diabetic rat
Diabetes, 1981The transport kinetics across the plasma-aqueous and plasma-vitreous barriers were studied in normal and long-term streptozotocin-diabetic rats, using trace amounts of [14C]-L-glucose and [3H]-3-O-methyl-D-glucose. The former is passively transported while the latter uses the same transport-facilitating system as D-glucose. Transport rates of L-glucose
J, DiMattio +3 more
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The Conjunctival Barrier in Ocular Drug Delivery
2007Within the context of topical and local drug delivery to the eye, the mammalian conjunctiva functions as a unique biological barrier. Various model systems as in vitro tools have been refined and validated over the years to assess drug absorption across the conjunctiva.
Hovhannes J. Gukasyan +2 more
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Disruption of blood-retinal barrier in ocular hypotony: Preliminary report
Experimental Eye Research, 1976Abstract Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier.
M O, Tso, C Y, Shih
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Osmotic opening of blood-brain and blood-ocular barriers
Experimental Eye Research, 1977Barriers in the eye and brain are composed of layers of cells that are connected by tight junctions which restrict intercellular diffusion. Exposure to hypertonie solutions increases the permeability of these barriers at blood vessels of the brain, retina and optic nerve (but not of the iris), and at the pigmented retinal epithelium and ciliary ...
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