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Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery [PDF]
PharmaceuticalsOcular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off ...
Eslim Batur +3 more
doaj +5 more sources
Penetration enhancers in ocular drug delivery [PDF]
Pharmaceutics, 2019 There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science.
Abdulrazik +38 more
core +6 more sources
Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions [PDF]
Micromachines, 2023 Drug delivery to the anterior and posterior segments of the eye is impeded by anatomical and physiological barriers. Increasingly, the bioeffects produced by ultrasound are being proven effective for mitigating the impact of these barriers on ocular drug
Blair Duncan +4 more
doaj +2 more sources
Updates on Biodegradable Formulations for Ocular Drug Delivery [PDF]
Pharmaceutics, 2023 The complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes.
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
doaj +2 more sources
Polysaccharides in Ocular Drug Delivery [PDF]
Pharmaceutics, 2019 Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies.
Natallia Dubashynskaya +4 more
doaj +4 more sources
Lipid-based nanoparticles: innovations in ocular drug delivery [PDF]
Frontiers in Molecular BiosciencesOcular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, and degradative enzymes) within the eye.
Mirza Salman Baig +12 more
doaj +2 more sources
How to Fabricate Hyaluronic Acid for Ocular Drug Delivery [PDF]
PharmaceuticsThis review aims to examine existing research on the development of ocular drug delivery devices utilizing hyaluronic acid (HA). Renowned for its exceptional biocompatibility, viscoelastic properties, and ability to enhance drug bioavailability, HA is a ...
Martha Kim +5 more
doaj +2 more sources
Nanotechnology-based ocular drug delivery systems: recent advances and future prospects [PDF]
Journal of Nanobiotechnology, 2023 Ocular drug delivery has constantly challenged ophthalmologists and drug delivery scientists due to various anatomical and physiological barriers. Static and dynamic ocular barriers prevent the entry of exogenous substances and impede therapeutic agents'
Shiding Li, Liangbo Chen, Yao Fu
doaj +2 more sources
Ocular Drug Delivery: Emerging Approaches and Advances [PDF]
PharmaceuticsComplex anatomical and physiological barriers make the eye a challenging organ to treat from a drug delivery perspective. Currently available treatment methods (topical eyedrops) for anterior segment diseases pose several limitations in terms of ...
Shilpkala Gade +8 more
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Nanoparticles in Ocular Drug Delivery Systems. [PDF]
Pharmaceutics, 2023 Conventional ophthalmic formulations lack a prolonged drug release effect and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting low bioavailability with a consequent reduction in therapeutic efficacy [...]
Almeida H, Silva AC.
europepmc +4 more sources