Results 1 to 10 of about 22,138 (115)
Ocular Barriers and Their Influence on Gene Therapy Products Delivery [PDF]
Pharmaceutics, 2022 The eye is formed by tissues and cavities that contain liquids whose compositions are highly regulated to ensure their optical properties and their immune and metabolic functions.
Bastien Leclercq +2 more
doaj +4 more sources
Liposomal Drug Delivery in Ocular Therapy: Strategies for Enhancing Corneal Penetration and Bioavailability [PDF]
CellsVision impairment affects approximately 2.2 billion people worldwide, with glaucoma, age-related macular degeneration, fungal keratitis, and diabetic retinopathy among the leading causes of preventable blindness.
Palak Mehta +3 more
doaj +2 more sources
BMEMatPosterior segment eye diseases (PSEDs) remain a leading cause of irreversible blindness, with the eye's dynamic and static barriers posing challenges to effective drug delivery through different administration routes.
Yifan Shen +7 more
doaj +2 more sources
Nano-drops of biomimetic macromolecular drugs based on macrophage membranes for targeted treatment of fundus diseases [PDF]
Materials Today BioOcular fundus diseases—including age-related macular degeneration and diabetic retinopathy—are leading causes of irreversible vision loss worldwide. Current macromolecular therapies require frequent intravitreal injections, which increase patient burden ...
Yongguo Xiang +14 more
doaj +2 more sources
Nanomedicine for Treating Diabetic Retinopathy Vascular Degeneration
International Journal of Translational Medicine, 2021 The incidence of diabetes and the pathological conditions associated with chronic hyperglycemia is increasing worldwide. Among them, diabetic retinopathy represents a leading cause of vision loss, causing a significant structural and functional ...
Tatiana Borodina +3 more
doaj +1 more source
Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases
Pharmaceutics, 2021 Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye.
Jose Navarro-Partida +5 more
doaj +1 more source
Topical Drug Delivery to the Posterior Segment of the Eye
Pharmaceutics, 2022 Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that
Marina Löscher +3 more
doaj +1 more source
Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions
Micromachines, 2023 Drug delivery to the anterior and posterior segments of the eye is impeded by anatomical and physiological barriers. Increasingly, the bioeffects produced by ultrasound are being proven effective for mitigating the impact of these barriers on ocular drug
Blair Duncan +4 more
doaj +1 more source
Lipid Nanoparticles for the Posterior Eye Segment
Pharmaceutics, 2021 This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most
Lorena Bonilla +8 more
doaj +1 more source
Pharmaceutics, 2023 The eye’s intricate anatomical barriers pose significant challenges to the penetration, residence time, and bioavailability of topically applied medications, particularly in managing uveitis and neuro-ophthalmologic conditions.
Kevin Y. Wu +4 more
doaj +1 more source