Results 31 to 40 of about 1,164,846 (257)

Topographic relations between ocular dominance and orientation columns in the cat striate cortex [PDF]

, 1988
Löwel S, Bischof H-J, Leutenecker B, Singer W. Topographic relations between ocular dominance and orientation columns in the cat striate cortex. Experimental Brain Research.
Leutenecker, B., Löwel, Siegrid, Bischof, Hans-Joachim, Singer, W.   +3 more
core   +1 more source

Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension

, 2007
Objective To test the validity and generalizability of the Ocular Hypertension Treatment Study (OHTS) prediction model for the development of primary open-angle glaucoma (POAG) in a large independent sample of untreated ocular hypertensive individuals
N. Orzalesi, Ocular Hypertension Treatment Study Group, European Glaucoma Prevention Study Group, L.M. Rossetti   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Unraveling the Therapeutic Enigma of Liposomes in Ocular Drug Delivery

Journal of Bio-X Research
The ocular delivery of drugs has always presented a pharmaceutical challenge. Various ocular barriers, such as reflex blinking, tear turnover, epithelial tight junctions, metabolism in ocular tissues, efflux pumps, nasolacrimal drainage, and other blood ...
Sandip Karmakar, Sreejan Manna, Tamal Jana, Sougata Jana, Gouranga Nandi   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of inflammation and fibroblasts in conjunctival scarring in ocular mucous membrane pemphigoid [PDF]

, 2009
Ocular mucous membrane pemphigoid (ocular MMP) is a visually devastating disease where up to 30% of patients become blind due to the consequences of conjunctival inflammation and aggressive fibrosis.
Saw, V.P.J.
core  

Ocular rosacea

, 2005
Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea ...
Mannis, Mark J. [UNIFESP], Alvarenga, Lênio Souza [UNIFESP]   +1 more
core   +1 more source

Active trachoma and ocular Chlamydia trachomatis infection in two Gambian regions: on course for elimination by 2020? [PDF]

, 2009
BACKGROUND: Trachoma has been endemic in The Gambia for decades. National trachoma control activities have been in place since the mid-1980's, but with no mass antibiotic treatment campaign.
Chrissy H Roberts, Sarr Isatou, Esther Aryee, Edwards Tansy, Sillah Ansumana, Harding-Esch, Emma M, Sillah, Ansumana, Martin J Holland, Bailey Robin L., Molina, Sandra, Edwards, Tansy, Harding-Esch Emma M., Sandra Molina, David C W Mabey, Emma M Harding-Esch, Isatou Sarr, Snell Paul, Paul Snell, Tansy Edwards, Ansumana Sillah, Mabey David C. W., Roberts Chrissy H., Robin L Bailey, Bailey, Robin L, Holland, Martin J, Snell, Paul, Roberts, Chrissy H, Aryee Esther, Sarr, Isatou, Molina Sandra, Holland Martin J., Mabey, David CW, Aryee, Esther   +32 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source