Results 51 to 60 of about 1,164,846 (257)

A review on polymers in ocular drug delivery systems

MedComm – Biomaterials and Applications
Amid the escalating prevalence of eye diseases and the intricate nature of the eye as a crucial target organ for drug delivery, researchers face significant challenges in developing delivery systems tailored specifically for ocular complications ...
Amol C. Bisen, Arpon Biswas, Ayush Dubey, Sachin N. Sanap, Sristi Agrawal, Karan S. Yadav, Vaishali Singh, Priyanka Rawat, Sudhanshu Sagar, Madhav N. Mugale, Rabi S. Bhatta   +10 more
doaj   +1 more source

Comparison of Ocular Surface Mucin Expression After Topical Ophthalmic Drug Administration in Dry Eye-Induced Mouse Model

, 2018
PURPOSE: To determine the mucinogenic effect of dry eye (DE) treatment drugs currently in use, we compared the levels of mucin production and inflammatory cytokine expression on the ocular surfaces using a DE-induced mice model.
노혜미, 김현창, 여아름, 지용우, 문인희, 이형근, 강현구   +6 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Ophthalmology: Navigating ocular barriers with advanced nanocarriers

German Journal of Pharmaceuticals and Biomaterials
The unique anatomy and physiology of the eye present significant challenges for effective drug delivery, necessitating innovative approaches to manage ocular diseases.
Sanaul Mustafa
doaj   +1 more source

Ophthalmic Drug Delivery, 2nd Edition

, 2023
Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety.

core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Ocular involvement in Muckle-Wells syndrome

, 2020
Purpose: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS).Materials and Methods: Nine patients with MWS were included in this study.

core   +3 more sources

Clinical Characteristics of Ocular Mucous Membrane Pemphigoid: A Systematic Review and Meta-Analysis

Purpose: To synthesize the evidence and generate a combined weighted measure on the frequency of ocular manifestations of mucous membrane pemphigoid (OMMP).
Romero-Osorio M.J., Oliver-Hernández M.V., Romero-Santos S., Barragán A.M., Pardo-Pizza D., de-la-Torre A., Cifuentes-González C., Parra-Tanoux D., Bocanegra-Oyola N.   +8 more
core   +1 more source

Quality of life in purely ocular myasthenia in Japan [PDF]

, 2014
Background: Since there has been no conclusive evidence regarding the treatment of ocular myasthenia, treatment guidelines were recently issued by the European Federation of Neurological Societies/European Neurological Society (EFNS/ENS).
Murai, Hiroyuki, Shigeaki Suzuki, Motomura, Masakatsu, Emiko Tsuda, Shunya Nakane, Nagane, Yuriko, Masuda, Masayuki, Shingo Konno, Suzuki, Shigeaki, Tsuda, Emiko, Konno, Shingo, Hiroyuki Murai, Imai, Tomihiro, Suzuki, Norihiro, Tomihiro Imai, Oji, Satoru, Nakane, Shunya, Yuriko Nagane, Norihiro Suzuki, Utsugisawa, Kimiaki, Satoru Oji, Masayuki Masuda, Masakatsu Motomura, Kimiaki Utsugisawa   +23 more
core   +2 more sources

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source