Results 71 to 80 of about 1,164,846 (257)

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Design and synthesis of natural antibacterial derivatives for ocular tuberculosis: a comprehensive review

Frontiers in Pharmacology
Ocular tuberculosis (TB) is an underrecognized extrapulmonary manifestation of Mycobacterium tuberculosis (M. tuberculosis) infection that can result in irreversible vision loss.
Isaiah Osei Duah, Isaiah Osei Duah, Isaiah Osei Duah, Gabriel Amankwah, Gabriel Amankwah, Gabriel Amankwah, Josephine Ampong, Sherlene Brown, Bernice Lebene Tettey, Hubert Osei Acheampong, Hubert Osei Acheampong, Ruth Boahemaa Awuku, Cynthia Amaning Danquah   +12 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Long‐Acting Ocular Injectables: Are We Looking In The Right Direction?

Advanced Science
The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability.
Mickael Dang, Molly S. Shoichet
doaj   +1 more source

Pathophysiology of ocular surface squamous neoplasia. [PDF]

, 2014
The incidence of ocular surface squamous neoplasia (OSSN) is strongly associated with solar ultraviolet (UV) radiation, HIV and human papilloma virus (HPV). Africa has the highest incidence rates in the world.
Burton, Matthew J., Ohnuma, Shin-ichi, Sagoo, Mandeep S., Burton, Matthew J, Sagoo, Mandeep S, Gichuhi, Stephen   +5 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

, 2021
Objective Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1.
Bansal, Reema, Agrawal, Rupesh, Sharma, Aman, Moharana, Bruttendu, Bodaghi, Bahram, Pavesio, Carlos, Teoh, Stephen, Al-Dhibi, Hassan, Singh, Ramandeep, Gupta, Vishali, Chee, Soon-Phaik, Invernizzi, Alessandro, Kempen, John H., Lee, Richard, Mahajan, Sarakshi, Gunasekeran, Dinesh Visva, Vala, Ruchi, Tugal-Tutkun, Ilknur, Sharma, Kusum, Westcott, Mark, Barisani-Asenbauer, Talin, Narain, Shishir, Tasiopoulou, Anastasia, Zierhut, Manfred, Murthy, Somasheila, Gonzalez-Lopez, Julio J., Biswas, Jyotirmay, Kon, Onn Min, Babu, Kalpana, Cunningham, Emmett T., Goldstein, Debra A., Agarwal, Mamta, Jones, Nicholas, Basu, Soumayava, Androudi, Sofia, Agarwal, Aniruddha, Quan Dong Nguyen, Quan Dong Nguyen, Aggarwal, Kanika, Abraham, Sharanaya, Nadarajah, Sengal, Mahendradas, Padmamalini, Herbort, Carl P., Carreno, Ester, Mccluskey, Peter, Testi, Ilaria, Agarwal, Manisha, Cimino, Luca, Khairallah, Moncef, Raje, Dhananjay, Degli Esposti, Simona, Ho, Su Ling   +50 more
core   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Comprehensive Strategies for Overcoming Barriers in Ocular Drug Delivery: Current Trends and Future Directions

Biomedical Sciences and Clinical Medicine
The human eye is a complex and sensitive organ, making effective drug delivery a major challenge. Its anatomical barriers, such as the precorneal, corneal, and blood-ocular barriers, significantly limit drug penetration and retention.
Elavarasan N, S. Revathi, K. Venkateshwaran   +2 more
doaj   +1 more source

Ocular morbidity and utilisation of protective eyewear among carpenters in Mushin local government, Lagos, Nigeria

Nigerian Postgraduate Medical Journal, 2019
Context: Proper use of protective eyewear (PEW) is important in the prevention of occupational eye injury. Aim: The aim of this study was to determine the ocular morbidity and utilisation of PEW among carpenters in Mushin Local Government, Lagos, with a ...
Onyinyechukwu Mary-Angela Onyekwelu, Olufisayo Temitayo Aribaba, Kareem Olatunbosun Musa, Oluwatobi Olalekan Idowu, Monsurah Olabimpe Salami, Yvonne Nwamaka Odiaka   +5 more
doaj   +1 more source