Results 21 to 30 of about 30,941 (247)
The AAPS Journal, 2010 Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution ...
Ripal, Gaudana +3 more
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Ocular prodrugs: Attributes and challenges
Asian Journal of Pharmaceutical Sciences, 2021 Ocular drug delivery is one of the most attention-grabbing and challenging endeavors among the numerous existing drug delivery systems. From a drug delivery point of view, eye is an intricate organ to investigate and explore. In spite of many limitations,
Jagpreet kour, Neha Kumari, Bharti Sapra
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Dendrimers for ocular drug delivery [PDF]
Canadian Journal of Chemistry, 2017 Existing methods of administering ocular drugs are limited in either their safety or efficiency. Nanomedicine therapies have the potential to address this deficiency by creating vehicles that can control drug biodistribution. Dendrimers are synthetic polymeric nanoparticles with a unique, highly organized branching structure.
Michael G, Lancina, Hu, Yang
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MRI in ocular drug delivery [PDF]
NMR in Biomedicine, 2008 AbstractConventional pharmacokinetic methods for studying ocular drug delivery are invasive and cannot be conveniently applied to humans. The advancement of MRI technology has provided new opportunities in ocular drug‐delivery research. MRI provides a means to non‐invasively and continuously monitor ocular drug‐delivery systems with a contrast agent or
S Kevin, Li +2 more
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Disease Models & Mechanisms, 2017 Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma filtration surgery (GFS).
Li-Fong Seet +5 more
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Pharmaceutics, 2023 Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations ...
Letizia Pelusi +6 more
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Drug Delivery, 2023 Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li +12 more
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Revolutionizing ocular drug delivery: recent advancements in in situ gel technology
Bulletin of the National Research Centre, 2023 Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug.
Susanta Paul +2 more
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A Review on Ocular Novel Drug Delivery Systems of Antifungal Drugs: Functional Evaluation and Comparison of Conventional and Novel Dosage Forms [PDF]
Advanced Pharmaceutical Bulletin, 2021 Ocular fungal infections affect more than one million people annually worldwide. They can lead to impaired vision or even complete blindness, so they should be treated immediately to prevent such consequences.
Saba Mehrandish, Shahla Mirzaeei
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Research progress of in-situ gelling ophthalmic drug delivery system
Asian Journal of Pharmaceutical Sciences, 2019 Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various ...
Yumei Wu +9 more
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