Results 21 to 30 of about 32,854 (248)

Dendrimers for ocular drug delivery [PDF]

Canadian Journal of Chemistry, 2017
Existing methods of administering ocular drugs are limited in either their safety or efficiency. Nanomedicine therapies have the potential to address this deficiency by creating vehicles that can control drug biodistribution. Dendrimers are synthetic polymeric nanoparticles with a unique, highly organized branching structure.
Michael G, Lancina, Hu, Yang
openaire   +2 more sources

Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis

Disease Models & Mechanisms, 2017
Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma filtration surgery (GFS).
Li-Fong Seet, Li Zhen Toh, Stephanie W. L. Chu, Sharon N. Finger, Jocelyn L. L. Chua, Tina T. Wong   +5 more
doaj   +1 more source

Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases Treatment: Focusing on Drug-Loaded Ocular Inserts, Contacts, and Intraocular Lenses

Pharmaceutics, 2023
Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations ...
Letizia Pelusi, Domitilla Mandatori, Leonardo Mastropasqua, Luca Agnifili, Marcello Allegretti, Mario Nubile, Assunta Pandolfi   +6 more
doaj   +1 more source

Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Drug Delivery, 2023
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou   +12 more
doaj   +1 more source

Revolutionizing ocular drug delivery: recent advancements in in situ gel technology

Bulletin of the National Research Centre, 2023
Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug.
Susanta Paul, Subhabrota Majumdar, Mainak Chakraborty   +2 more
doaj   +1 more source

A Review on Ocular Novel Drug Delivery Systems of Antifungal Drugs: Functional Evaluation and Comparison of Conventional and Novel Dosage Forms [PDF]

Advanced Pharmaceutical Bulletin, 2021
Ocular fungal infections affect more than one million people annually worldwide. They can lead to impaired vision or even complete blindness, so they should be treated immediately to prevent such consequences.
Saba Mehrandish, Shahla Mirzaeei
doaj   +1 more source

Research progress of in-situ gelling ophthalmic drug delivery system

Asian Journal of Pharmaceutical Sciences, 2019
Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various ...
Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawei Li, Shouying Du, Zhidong Liu   +9 more
doaj   +1 more source

New Challenges in Ocular Drug Delivery. [PDF]

Pharmaceutics
The clinical treatment of diseases affecting the eye globe, and specifically the retina and posterior eye segment, is often hindered by the physiological protection structures and mechanisms of the organ, as well as by the unsuitable physico-chemical features of the active molecules [...]
Pignatello R, Almeida H, Santonocito D, Puglia C.   +3 more
europepmc   +5 more sources

Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances

Pharmaceutics, 2022
Due to complicated anatomical and physical properties, targeted drug delivery to ocular tissues continues to be a key challenge for formulation scientists.
Shery Jacob, Anroop B. Nair, Jigar Shah, Sumeet Gupta, Sai H. S. Boddu, Nagaraja Sreeharsha, Alex Joseph, Pottathil Shinu, Mohamed A. Morsy   +8 more
doaj   +1 more source

Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma

Frontiers in Cell and Developmental Biology
Glaucoma is a complex disease of the optic nerve leading to vision loss and blindness, with high worldwide incidence and disproportionate prevalence in older populations.
Nisha Rajakrishna, Nisha Rajakrishna, Seok Ting Lim, Seok Ting Lim, Xiaomeng Wang, Xiaomeng Wang, Xiaomeng Wang, Tina T. Wong, Tina T. Wong, Tina T. Wong   +9 more
doaj   +1 more source