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International Journal of Advanced Research in Science, Communication and Technology, 2023 The projected advent of new medications with short biological half-lives, whose efficacy may depend on a more continuous drug supply than eyedrops can offer, is one reason why innovative ocular drug delivery methods are currently garnering more consideration. moreover due to the possibility for various delivery methods to lessen the negative effects of
null Nikita Jadhav +2 more
openaire +1 more source
Drug Delivery, 2023 Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li +12 more
doaj +1 more source
Nanogels for pharmaceutical and biomedical applications and their fabrication using 3D printing technologies [PDF]
, 2018 Nanogels are hydrogels formed by connecting nanoscopic micelles dispersed in an aqueous medium, which give an opportunity for incorporating hydrophilic payloads to the exterior of the micellar networks and hydrophobic payloads in the core of the micelles.
Cho, Hyunah +2 more
core +3 more sources
Enzyme replacement therapies: What is the best option? [PDF]
, 2018 Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh +4 more
core +2 more sources
Revolutionizing ocular drug delivery: recent advancements in in situ gel technology
Bulletin of the National Research Centre, 2023 Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug.
Susanta Paul +2 more
doaj +1 more source
A Review on Ocular Novel Drug Delivery Systems of Antifungal Drugs: Functional Evaluation and Comparison of Conventional and Novel Dosage Forms [PDF]
Advanced Pharmaceutical Bulletin, 2021 Ocular fungal infections affect more than one million people annually worldwide. They can lead to impaired vision or even complete blindness, so they should be treated immediately to prevent such consequences.
Saba Mehrandish, Shahla Mirzaeei
doaj +1 more source
Vectorisation intra-oculaire [Drug delivery to target the posterior segment of the eye]. [PDF]
, 2004 Retinal diseases are nowadays the most common causes of vision threatening in developed countries. Therapeutic advances in this field are hindered by the difficulty to deliver drugs to the posterior segment of the eye.
Behar-Cohen, F.
core +1 more source
Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]
, 2017 The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico +5 more
core +1 more source
Minimally invasive microneedles for ocular drug delivery [PDF]
, 2016 Introduction: Anterior and posterior segment eye diseases are highly challenging to treat, due to the barrier properties and relative inaccessibility of the ocular tissues.
Donnelly, Ryan F. +5 more
core +1 more source
Research progress of in-situ gelling ophthalmic drug delivery system
Asian Journal of Pharmaceutical Sciences, 2019 Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various ...
Yumei Wu +9 more
doaj +1 more source