Results 61 to 70 of about 1,264,680 (377)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study [PDF]

, 2010
Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study.
Blank, L., Geskus, R., Mourits, M., Nowak, P., Rootman, J., Saeed, P., Selva-Nayagam, D., Weis, E., Wolbers, J.   +8 more
core   +9 more sources

Association of severity of primary open-angle glaucoma with serum vitamin D levels in patients of African descent. [PDF]

, 2019
PurposeTo study the relationship between primary open-angle glaucoma (POAG) in a cohort of patients of African descent (AD) and serum vitamin D levels.MethodsA subset of the AD and glaucoma evaluation study III (ADAGES III) cohort, consisting of 357 ...
ADAGES III Genomics Study Group, Arzumanyan, Zorayr, Ayyagari, Radha, Chen, Yii-der I, Dirkes, Keri, Dubiner, Harvey, Feldman, Robert, Girkin, Christopher A, Guo, Xiuqing, Hai, Yang, Hammel, Naama, Holman, Matt, Liebmann, Jeffrey M, Rotter, Jerome I, Slight, Rigby, Taylor, Kent D, Weinreb, Robert N, Zangwill, Linda M   +17 more
core  

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Türk Oftalmoloji Dergisi, 2020
Objectives:To evaluate the diagnostic accuracy of the macular ganglion cell complex-to-total retinal thickness (G/T) ratio in a Caucasian population.Materials and Methods:A total of 86 patients were enrolled in this cross-sectional study.
Almila Sarıgül Sezenöz, Sirel Gür Güngör, Ahmet Akman, Caner Öztürk, Şefik Cezairlioğlu, Mustafa Aksoy, Meriç Çolak   +6 more
doaj   +1 more source

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

Frontiers in Molecular Neuroscience, 2019
Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial activation and neuroinflammation in the retina. Glial activation and release of pro-inflammatory cytokines TNFα and IL-1β, complement, and other danger factors was ...
A. Pronin, D. Pham, W. An, Galina Dvoriantchikova, Galina Reshetnikova, Jianzhong Qiao, Zhanna Kozhekbaeva, Ashlyn E. Reiser, V. Slepak, V. Shestopalov   +9 more
semanticscholar   +1 more source

Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography. [PDF]

, 2020
Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source ...
Araie, Makoto, Ibuki, Hisashi, Kanno, Junji, Shinoda, Kei, Shoji, Takuhei, Weinreb, Robert N, Yoshikawa, Yuji   +6 more
core  

Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study. [PDF]

, 2018
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients.
Galli, Fabio, Hollander, Lital, Italian Study Group on QoL in Glaucoma, Katsanos, Andreas, Oddone, Francesco, Poli, Davide, Quaranta, Luciano, Riva, Ivano, Rulli, Eliana, Torri, Valter, Weinreb, Robert N   +10 more
core   +2 more sources

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Widening use of dexamethasone implant for the treatment of macular edema [PDF]

, 2017
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.
Avitabile T., Bonfiglio V., Fallico M., Fichera S., Longo A., Macchi I., Pizzo A., Rapisarda C., Reibaldi M., Russo A.   +9 more
core   +2 more sources