Results 61 to 70 of about 306,256 (292)

Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension

open access: yes, 2007
Objective To test the validity and generalizability of the Ocular Hypertension Treatment Study (OHTS) prediction model for the development of primary open-angle glaucoma (POAG) in a large independent sample of untreated ocular hypertensive individuals
N. Orzalesi   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Investigation of the differential susceptibility of extraocular muscles in patients diagnosed with ocular myasthenia gravis based on the computerized diplopia test and the Ocular Motor Nerve Palsy Scale

open access: yesFrontiers in Neurology
IntroductionThe pattern of extraocular muscle involvement in ocular myasthenia gravis varies across different reports, diverging from our own observations.
Yi-fei Fan   +5 more
doaj   +1 more source

Unusual ocular manifestations of silent sinus syndrome

open access: yesRevista Brasileira de Oftalmologia, 2014
Silent sinus syndrome is an acquired condition in which there is a gradual collapse of the orbital floor and inward retraction of the maxillary sinus (atelectasis of the maxillary sinus).
Fabricio Lopes da Fonseca   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Color Vision Deficits and Binocular Vision Dysfunction in Parkinson’s Disease

open access: yesBrain Sciences
Background/Objectives: Visual dysfunction is a common non-motor symptom in Parkinson’s Disease (PD), as evidenced by deficits in color vision (CV) and binocular vision (BV). Computerized CV tests, such as the Cambridge Color Test (CCT), are underutilized
Julia Mleczek   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Ocular motility consequences following lesions of the thalamus: a literature review

open access: yesBritish and Irish Orthoptic Journal, 2009
Aim: To summarise the anatomy and function of the thalamus and review the medical literature for types of thalamic lesions and resultant ocular motility deficits. Methods: A literature search was undertaken using the PubMed and Web of Knowledge databases.
Elinor Elinor, Fiona J. Rowe
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Impact of Microscopic Motility on the Swimming Behavior of Parasites : Straighter Trypanosomes are More Directional [PDF]

open access: yes, 2011
Microorganisms, particularly parasites, have developed sophisticated swimming mechanisms to cope with a varied range of environments. African Trypanosomes, causative agents of fatal illness in humans and animals, use an insect vector (the Tsetse fly) to ...
Nagler, J.   +21 more
core   +2 more sources

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