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JAMA, 1964
A CAREFULLY CONDUCTED CLINICAL TRIAL is the most efficient means by which to determine the usefulness of a particular treatment in a particular disease. Sometimes a treatment is so obviously effective that a clinical trial serves primarily to establish its usefulness relative to other treatments and to the severity of disease.
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A CAREFULLY CONDUCTED CLINICAL TRIAL is the most efficient means by which to determine the usefulness of a particular treatment in a particular disease. Sometimes a treatment is so obviously effective that a clinical trial serves primarily to establish its usefulness relative to other treatments and to the severity of disease.
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Update on Ocular Myasthenia Gravis
Neurologic Clinics, 2017Ocular myasthenia gravis (OMG) is a localized form of myasthenia gravis in which autoantibodies directed against acetylcholine receptors block or destroy these receptors at the postsynaptic neuromuscular junction. The hallmark of OMG is a history of painless weakness or fatigability of the extraocular muscles and ptosis with normal pupillary function ...
Stacy V, Smith, Andrew G, Lee
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Current Opinion in Ophthalmology, 1996
Ocular myasthenia gravis may mimic any pupil-spared, painless, nonproptotic ophthalmoplegia with or without ptosis. This review references recent papers regarding clinical features, diagnostic techniques, and treatment for ocular myasthenia gravis.
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Ocular myasthenia gravis may mimic any pupil-spared, painless, nonproptotic ophthalmoplegia with or without ptosis. This review references recent papers regarding clinical features, diagnostic techniques, and treatment for ocular myasthenia gravis.
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Update on Ocular Myasthenia Gravis
Seminars in Neurology, 2019AbstractMyasthenia gravis is an antibody-mediated autoimmune disorder of the post-synaptic neuromuscular junction resulting in fluctuating, fatigable weakness. Most patients first present with extraocular symptoms (diplopia and/or ptosis), and in 15% of cases symptoms will remain restricted to only the extraocular muscles (ocular myasthenia gravis [OMG]
Meabh, O'Hare, Christopher, Doughty
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2011
Ocular myasthenia typically causes intermittent or fluctuating ptosis and diplopia but is often difficult to diagnose definitively. We discuss the approach to the patient with suspected ocular myasthenia but no acetylcholine-receptor antibodies, and review the treatment options for ocular myasthenia.
Matthew J. Thurtell +2 more
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Ocular myasthenia typically causes intermittent or fluctuating ptosis and diplopia but is often difficult to diagnose definitively. We discuss the approach to the patient with suspected ocular myasthenia but no acetylcholine-receptor antibodies, and review the treatment options for ocular myasthenia.
Matthew J. Thurtell +2 more
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2019
Ocular myasthenia typically causes intermittent or fluctuating ptosis and diplopia yet can be difficult to diagnose definitively. In this chapter, we begin by reviewing the symptoms and signs of ocular myasthenia. We next discuss the laboratory workup for antibodies that are associated with ocular myasthenia and describe bedside tests that can helpful ...
Matthew J. Thurtell, Robert L. Tomsak
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Ocular myasthenia typically causes intermittent or fluctuating ptosis and diplopia yet can be difficult to diagnose definitively. In this chapter, we begin by reviewing the symptoms and signs of ocular myasthenia. We next discuss the laboratory workup for antibodies that are associated with ocular myasthenia and describe bedside tests that can helpful ...
Matthew J. Thurtell, Robert L. Tomsak
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Childhood ocular myasthenia gravis
Ophthalmology, 2003To investigate the clinical manifestations and ocular findings in children with ocular myasthenia gravis (MG) that rarely have been reported in the literature.Retrospective, noncomparative case series.Twenty-four consecutive patients less than 15 years of age with ocular MG treated between June 1988 and July 2001.The medical records of 6 boys and 18 ...
Jong-Hyun, Kim +4 more
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Treatment of Ocular Myasthenia Gravis
Current Treatment Options in Neurology, 2011Myasthenia gravis (MG) is an autoimmune disorder that is characterized by variable weakness and fatigability. Often, MG presents with only ocular symptoms such as ptosis and diplopia. Treatment of ocular MG is aimed at relieving the symptoms of ptosis and diplopia, as well as preventing the development of generalized MG symptoms.
Scott R, Haines, Matthew J, Thurtell
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Pediatric Ocular Myasthenia Gravis
Current Treatment Options in Neurology, 2019We present a review of current strategies in the treatment of pediatric ocular myasthenia gravis (OMG). A critical appraisal was performed of the current literature available on OMG and the treatment options available for all age populations. From this data, we present the evidence surrounding therapeutic options for pediatric OMG and discuss treatment
Kristen, Fisher, Veeral, Shah
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Mycophenolate mofetil for ocular myasthenia
Journal of Neurology, 2008To study the safety and tolerability of mycophenolate mofetil (MM), since this steroid-sparing immunomodulatory agent with less side effects, compared to corticosteroids, may be considered for long-term management of ocular myasthenia (OMG).Consecutive patients with OMG started on MM between December 2000 and December 2002 were followed up to December ...
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