Results 81 to 90 of about 18,079 (270)

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

eHealth Solutions for Symptom Assessment and Monitoring in Adults With Chronic Kidney Disease: A Systematic Review

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims This systematic review examined eHealth solutions used to assess and monitor symptoms among adults with CKD. Design A systematic review was conducted and reported in accordance with the PRISMA checklist. The review protocol was registered in PROSPERO (CRD4202452973).
Khanh Linh Bui, Louise Purtell, Areum Hyun, Ann Bonner   +3 more
wiley   +1 more source

Scrub typhus‐associated movement and gait disorders: A systematic review with principal component analysis and in silico mechanistic modelling

Tropical Medicine &International Health, EarlyView.
Abstract Background Orientia tsutsugamushi, the causative agent of scrub typhus, is increasingly recognised for its neurological complications. Among these, movement and gait disorders are poorly understood. We systematically examined their clinical spectrum and explored underlying mechanisms through in‐silico protein–protein interaction modelling ...
Ritwick Mondal, Shramana Deb, Mrinmay Dhauria, Purbita Sen, Vramanti Sarkar, Shramana Sarkar, Dipanjan Chowdhury, Durjoy Lahiri, Jayanta Roy, Julián Benito‐León   +9 more
wiley   +1 more source

Congenital Fibrosis of Extraocular Muscles

Pediatric Neurology Briefs, 1997
The intracranial and orbital pathology and muscle pathology of chromosome 12-linked congenital fibrosis of the extraocular muscles are described in 3 affected members of a family in a report from Children’s Hospital, Harvard Medical School, Boston, and ...
J Gordon Millichap
doaj   +1 more source

An Open-Source OpenSim Oculomotor Model for Kinematics and Dynamics Simulation [PDF]

arXiv, 2018
Physics-based modeling and dynamic simulation of human eye movements has significant implications for improving our understanding of the oculomotor system and treating various visuomotor disorders. We introduce an open-source biomechanical model of the human eye that can be used for kinematics and dynamics analysis.
arxiv  

Towards an efficient inverse static model of a Festo actuator made of two antagonist muscles for hybrid control of its position and stiffness [PDF]

arXiv, 2021
The Festo air muscle is today one of the most known commercial version of the so-called McKibben pneumatic artificial muscle. A major advantage of handmade McKibben muscles, as well as its commercial versions, lies in the possibility it offers of realizing antagonist muscle actuator on the model of the biceps-triceps system.
arxiv  

Atypical Beta Oscillatory Dynamics Are Related to Poor Procedural Learning in Children With Developmental Coordination Disorder

Developmental Science, Volume 28, Issue 4, July 2025.
ABSTRACT Procedural learning difficulties are commonly reported in children with developmental coordination disorder (DCD), yet the neural basis of this impairment remains unclear. This study addressed this gap by examining the correlation between cortical oscillatory activity and procedural learning of a sequence of finger movements in children with ...
Jarrad A. G. Lum, Kaila M. Hamilton, Li‐Ann Leow, Welber Marinovic, Ian Fuelscher, Pamela Barhoun, Talitha C. Ford, Aron T. Hill, Samaneh Nahravani, Melissa Kirkovski, Peter G. Enticott, Christian Hyde   +11 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Precise Few-shot Fat-free Thigh Muscle Segmentation in T1-weighted MRI [PDF]

arXiv, 2023
Precise thigh muscle volumes are crucial to monitor the motor functionality of patients with diseases that may result in various degrees of thigh muscle loss. T1-weighted MRI is the default surrogate to obtain thigh muscle masks due to its contrast between muscle and fat signals.
arxiv  

An Euler-Bernoulli-Type Beam Model of the Vocal Folds for Describing Curved and Incomplete Glottal Closure Patterns [PDF]

arXiv, 2023
Incomplete glottal closure is a laryngeal configuration wherein the glottis is not fully obstructed prior to phonation. In this work, we introduce an Euler-Bernoulli composite beam vocal fold (VF) model that produces qualitatively similar incomplete glottal closure patterns as those observed in experimental and high-fidelity numerical studies, thus ...
arxiv