Investigation of the Role and Mechanism of Rapamycin on Senile Osteoporosis via Osteocyte Autophagy [PDF]
, 2016 背景：老年性骨质疏松症患病人数逐年攀升，已成为严重的公共卫生问题。最新研究表明：骨细胞通过调节成骨细胞和破骨细胞的功能，从而主导骨重建。随着年龄增长，骨细胞凋亡增加，数目减少，导致骨代谢紊乱。细胞自噬是一种重要的生理机制，可以协助维持骨细胞活性。研究表明，因年龄增加而导致的骨细胞自噬功能障碍与老年性骨质疏松症的发病密切相关。因此，本课题以骨细胞自噬为切入点，选取经典的自噬诱导剂雷帕霉素，探究其对于老年性骨质疏松症的作用及可能机制。 方法：将52只24月龄SD大鼠随机分为雷帕霉素组和对照组 ...
罗德庆
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New horizons in treatment of osteoporosis [PDF]
, 2017 BACKGROUND: Prevalence of osteoporosis is increasing both in developed and developing countries. Due to rapid growth in the burden and cost of osteoporosis, worldwide, it seems reasonable to focus on the reduction of fractures as the main goal of ...
Khashayar, Patricia +3 more
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Causes, consequences, and treatment of osteoporosis in men
Drug Design, Development and Therapy, 2013 Jameela Banu Coordinated Program in Dietetics, College of Health Sciences and Human Services and Department of Biology, College of Science and Mathematics, University of Texas-Pan American, Edinburg, TX, USA Abstract: Men undergo gradual bone loss with ...
Banu J
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Why Leave a Job Half Done? Recent Progress in Enzymatic Deracemizations [PDF]
, 2015 Financial support of this work by the Spanish MICINN (Projects CTQ2011-24237 and CTQ2013-44153) is gratefully ...
Díaz Rodríguez, Alba +2 more
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Therapeutic targets for bone metastases in breast cancer [PDF]
, 2011 Breast cancer is prone to metastasize to bone. Once metastatic cells are in the bone marrow, they do not, on their own, destroy bone. Instead, they alter the functions of bone-resorbing (osteoclasts) and bone-forming cells (osteoblasts), resulting in ...
A Bandyopadhyay +53 more
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Emerging strategies and therapies for treatment of Paget’s disease of bone
Drug Design, Development and Therapy, 2011 Laëtitia Michou, Jacques P BrownLaval University, Department of Medicine, CHUQ (CHUL) Research Centre and Division of Rheumatology, Quebec City, QC, CanadaAbstract: Paget’s disease of bone (PDB) is a progressive monostotic or ...
Brown JP, Michou L
doaj
Intervenciones no farmacológicas en la osteoporosis [PDF]
, 2015 Introducción: La osteoporosis es el proceso metabólico óseo más frecuente, caracterizado por la disminución de la resistencia ósea, que conlleva un aumento del riesgo de fracturas.
Fernández Gutiérrez, Miriam
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Odanacatib: Location and timing are everything [PDF]
Journal of Bone and Mineral Research, 2012 openaire +2 more sources
High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group [PDF]
, 2013 core +1 more source
Bone marrow Fat - A Novel Quantification Method and Potential Clinical Applications [PDF]
, 2017 Ageing bone is characterised by increased marrow fat infiltration altering its composition and microstructure, thus predisposing the person to osteoporosis.
Demontiero, Oddom Samban
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