Results 11 to 20 of about 1,795 (205)

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo [PDF]

Pharmaceuticals, 2016
Hookworm infection is chief among soil-transmitted helminthiases (STHs) for the chronic morbidly inflicted. Deworming via mass drug administration (MDA) programs most often employs single doses of benzimidazole drugs to which resistance is a constant ...
Jon J. Vermeire, Brian M. Suzuki, Conor R. Caffrey   +2 more
doaj   +6 more sources

Odanacatib [PDF]

Definitions, 2020
An inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in ...

semanticscholar   +2 more sources

Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis [PDF]

The Journal of Clinical Investigation
Elevated angiopoietin-2 is associated with diverse inflammatory conditions, including sepsis, a leading global cause of mortality. During inflammation, angiopoietin-2 antagonizes the endothelium-enriched receptor Tie2 to destabilize the vasculature.
Takashi Suzuki, Erik Loyde, Sara Chen, Valerie Etzrodt, Temitayo O. Idowu, Amanda J. Clark, Marie Christelle Saade, Brenda Mendoza Flores, Shulin Lu, Gabriel Birrane, Vamsidhara Vemireddy, Benjamin Seeliger, Sascha David, Samir M. Parikh   +13 more
doaj   +2 more sources

Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis

Bone Reports, 2017
The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treatment
Antonio Cabal, Donald S. Williams, Richa Y. Jayakar, Jingru Zhang, Swanand Sardesai, Le T. Duong   +5 more
doaj   +2 more sources

In silico Guided Drug Repurposing: Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2 [PDF]

Frontiers in Chemistry, 2019
Malaria is among the leading causes of death worldwide. The emergence of Plasmodium falciparum resistant strains with reduced sensitivity to the first line combination therapy and suboptimal responses to insecticides used for Anopheles vector management ...
Lucas N. Alberca, Sara R. Chuguransky, Cora L. Álvarez, Alan Talevi, Emir Salas-Sarduy   +4 more
doaj   +3 more sources

The impact of medication on osseointegration and implant anchorage in bone determined using removal torque—A review [PDF]

Heliyon, 2022
Permanently anchored metal implants are frequently used in dental, craniomaxillofacial, and orthopaedic rehabilitation. The success of such therapies is owed to the phenomenon of osseointegration—the direct connection between the living bone and the ...
Martina Jolic, Sonali Sharma, Anders Palmquist, Furqan A. Shah   +3 more
doaj   +2 more sources

Odanacatib for the treatment of postmenopausal osteoporosis: Development history and design and participant characteristics of LoFT, the Long-term odanacatib Fracture Trial [PDF]

Osteoporosis International, 2015
Summary: Odanacatib is a cathepsin K inhibitor investigated for the treatment of postmenopausal osteoporosis. Phase 2 data indicate that 50 mg once weekly inhibits bone resorption and increases bone mineral density, with only a transient decrease in bone
Bone, Henry G., Dempster, David W., Eisman, John A., Greenspan, S. L., Leung, A. T., Lombardi, Antonio, McClung, Michael R., Nakamura, T., Papapoulos, S., Rybak-Feiglin, A., Santora, A. C., Shih, W. J., Verbruggen, Nadia   +12 more
core   +9 more sources

Potential role of odanacatib in the treatment of osteoporosis

Clinical Interventions in Aging, 2012
Kong Wah NgDepartment of Endocrinology and Diabetes and St Vincent’s Institute, St Vincent’s Hospital, Fitzroy, Victoria, AustraliaAbstract: Cathepsin K is a key enzyme involved in the degradation of organic bone matrix by osteoclasts ...
Ng KW
doaj   +5 more sources

Calcium-dependent pathway as a primary cause of hypoxic RGC damage in monkey retinal explants. [PDF]

PLoS ONE
PurposeRetinal ganglion cells (RGCs) loss or degeneration in the retina is a hallmark of many sight-threatening diseases, including glaucoma and retinopathy.
Emi Nakajima, Momoko Otsugu-Kobayashi, Takatoshi Uchida, Kana Orihara, Thomas R Shearer, Mitsuyoshi Azuma   +5 more
doaj   +2 more sources

Effects of Odanacatib on Bone Structure and Quality in Postmenopausal Women With Osteoporosis: 5‐Year Data From the Phase 3 Long‐Term Odanacatib Fracture Trial (LOFT) and its Extension

Journal of Bone and Mineral Research, 2020
Odanacatib (ODN), a selective oral inhibitor of cathepsin K, was an investigational agent previously in development for the treatment of osteoporosis.
R. Recker, D. Dempster, B. Langdahl, H. Giezek, Seth Clark, G. Ellis, T. de Villiers, I. Valter, C. Zerbini, D. Cohn, A. Santora, L. Duong   +11 more
semanticscholar   +3 more sources