Results 21 to 30 of about 1,795 (205)
Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis. [PDF]
British Journal of Clinical Pharmacology, 2019 Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme responsible for the degradation of bone collagen.
Julie A. Stone +4 more
semanticscholar +3 more sources
Brazilian Archives of Biology and Technology, 2017 Odanacatib (ODN) is a selective inhibitor of cathepsin K. The cysteine protease cathepsin K has been implicated in cardiac hypertrophy. Resistine is an adipokine which is identified to promote cardiac hypertrophy.
Xian Zheng +6 more
doaj +2 more sources
Merck &Co. drops osteoporosis drug odanacatib [PDF]
Nature Reviews Drug Discovery, 2016 Asher Mullard
semanticscholar +2 more sources
Odanacatib: the best osteoporosis treatment we never had?
The Lancet Diabetes & Endocrinology, 2019 Commentary
Louise Statham, T. Aspray
semanticscholar +5 more sources
Treatment with an inhibitor of matrix metalloproteinase 9 or cathepsin K lengthens embryonic lower jaw bone. [PDF]
Orthod Craniofac Res, 2023 Abstract Objectives Skeletal malocclusions are common, and severe malocclusions are treated by invasive surgeries. Recently, jaw bone length has been shown to be developmentally controlled by osteoclasts. Our objective was to determine the effect of inhibiting osteoclast‐secreted proteolytic enzymes on lower jaw bone length of avian embryos by ...
Houchen CJ +5 more
europepmc +2 more sources
Emerging therapeutic strategies targeting bone signaling pathways in periodontitis. [PDF]
J Periodontal ResAnti‐resorptive, immunomodulatory, and emerging therapeutic approaches to treat periodontal disease and promote resolution of inflammation. Abstract Periodontitis is a multifactorial immune‐mediated disease exacerbated by dysregulated alveolar bone homeostasis. Timely intervention is crucial for disease management to prevent tooth loss. To successfully
Valverde A, George A, Nares S, Naqvi AR.
europepmc +2 more sources
Journal of Bone and Mineral Research, 2021 We prospectively assessed, with predefined criteria, the location and rates of all femur fractures (hip, subtrochanteric/femoral shaft [ST/FS], including atypical [AFF] and distal fractures) in women at increased fracture risk during treatment with the ...
S. Papapoulos +11 more
semanticscholar +1 more source
Angewandte Chemie, Volume 135, Issue 18, April 24, 2023., 2023 Merging metal and enzyme catalysis provides multiple solutions for the synthesis of optically active molecules. To achieve this aim, both catalyst types need to work under similar reaction conditions avoiding mutual inactivation. Herein, successful one‐pot sequential and concurrent cascades are described for the design of high‐yielding transformations ...
Sergio González‐Granda +3 more
wiley +2 more sources
Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin-K Activity Detection, Revealing Nuclear Activity. [PDF]
Adv Sci (Weinh)Highly selective reversible‐ and irreversible covalent cathepsin K (CTSK) activity‐based probes are developed and applied to detect CTSK activity in human and mice samples, detecting changes in activity in pathological samples. These non‐toxic probes also enabled studying CTSK activation by pH changes, unique inhibition in cell lysates, and remarkable ...
Dey G +11 more
europepmc +2 more sources
Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
Biochemical Journal, 2017 Cathepsin K (CatK) is the predominant mammalian bone-degrading protease and thus an ideal target for antiosteoporotic drug development. Rodent models of osteoporosis are preferred due to their close reflection of the human disease and their ease of handling, genetic manipulation and economic affordability.
S. Law +6 more
semanticscholar +3 more sources