Results 31 to 40 of about 1,795 (205)
Redox Biology, 2022 Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear.
Seung Un Seo +9 more
doaj +1 more source
JBMR Plus, Volume 7, Issue 11, November 2023., 2023 Type 1 (T1D) and type 2 diabetes (T2D) are associated with an increased risk of fractures. Antiresorptive and anabolic therapies have shown efficacy in reducing fracture risk in individuals with T2D, but evidence is more robust for antiresorptive drugs. Evidence in T1D is scant.
Tatiane Vilaca, Richard Eastell
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 27, Issue 22, Page 3601-3613, November 2023., 2023 Abstract Osteoporosis is a prevalent complication of diabetes, characterized by systemic metabolic impairment of bone mass and microarchitecture, particularly in the spine. Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been extensively employed in Traditional Chinese Medicine to manage diabetes; however, its potential to ...
Fangda Fu +12 more
wiley +1 more source
Mechanistic advances in osteoporosis and anti‐osteoporosis therapies
MedComm, Volume 4, Issue 3, June 2023., 2023 Osteoporosis, a type of bone loss disease, causes enormous burden at both the human and socioeconomic layer. In this study, we systematically reviewed according literatures and clinical evidences to both mechanistically and clinically demonstrate the state‐of‐art advances on osteoporosis, and furthermore present the most updated anti‐osteoporosis ...
Haiwei Wang +5 more
wiley +1 more source
The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits [PDF]
, 2013 Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference?
Andersen, Thomas Levin +4 more
core +1 more source
New molecular targets in bone metastases [PDF]
, 2010 Bone metastases have a major impact on morbidity and on mortality in cancer patients. Despite its clinical relevance, metastasis remains the most poorly elucidated aspect of carcinogenesis.
Colucci, G. +14 more
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Journal of Extracellular Vesicles, Volume 12, Issue 3, March 2023., 2023 Abstract Bone metastases are still incurable and result in the development of clinical complications and decreased survival for prostate cancer patients. Recently, a number of studies have shown that extracellular vesicles (EVs) play important roles in tumour progression.
Fumihiko Urabe +8 more
wiley +1 more source
Periplaneta Americana extract inhibits osteoclastic differentiation in vitro
Cell Proliferation, Volume 56, Issue 2, February 2023., 2023 Periplaneta americana extract (PAE), the animal medicine material extracted from the insects Periplaneta americana, is proven to possess a variety of pharmacological functions. However, the role of PAE in skeletal disorders remains unclear. In this study, we found that PAE decreased osteoclast genes expression Nfatc1, Ctsk, and Acp5 in macrophages ...
Bin Zhao +5 more
wiley +1 more source
Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review [PDF]
, 2016 Throughout life, bone is continuously remodelled. Bone is formed by osteoblasts, from mesenchymal origin, while osteoclasts induce bone resorption. This process is tightly regulated. During inflammation, several growth factors and cytokines are increased
Alves, C.H. (Celso Henrique) +4 more
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Emerging Therapies for Osteoporosis [PDF]
Endocrinology and Metabolism, 2015 Although several effective therapies are available for the treatment of osteoporosis in postmenopausal women and older men, there remains a need for the development of even more effective and acceptable drugs.
Michael R. McClung
doaj +1 more source