Results 41 to 50 of about 1,795 (205)

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Effects of odanacatib on bone matrix mineralization in rhesus monkeys are similar to those of alendronate

Bone Reports, 2016
Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K which is an important enzyme for the degradation of collagen I. Aim of the present work was the head-to-head comparison between the effects of ODN and alendronate (ALN) on bone ...
Barbara M. Misof, Paul Roschger, Charles Chen, Maureen Pickarski, Phaedra Messmer, Klaus Klaushofer, Le T. Duong   +6 more
doaj   +1 more source

Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent [PDF]

, 2017
This paper reports the MEPS-HPLC-DAD method for the simultaneous determination of 12 azole drugs (bifonazole, butoconazole, clotrimazole, econazole, itraconazole, ketoconazole, miconazole, posaconazole, ravuconazole, terconazole, tioconazole and ...
Bellagamba, Giuseppe, Campestre, Cristina, Carradori, Simone, Celia, Christian, De Luca, Elisa, Di Marzio, Luisa, Guglielmi, Paolo, Locatelli, Marcello, Menta, Sergio, Zengin, Gokhan   +9 more
core   +3 more sources

VASCULAR CALCIFICATION, ATHEROSCLEROSIS AND BONE LOSS (OSTEOPOROSIS): NEW PATHOPHYSIOLOGICAL MECHANISMS AND FUTURE PERSPECTIVES FOR PHARMACOLOGICAL THERAPY

Alʹmanah Kliničeskoj Mediciny, 2016
Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated process, increasingly recognized as a general cardiovascular risk factor.
A. Dolzhenko, T. Richter, S. Sagalovsky
doaj   +1 more source

Loss of full-length pumilio 1 abrogates miRNA-221-induced gene p27 silencing-mediated cell proliferation in the heart

Molecular Therapy: Nucleic Acids, 2022
Upregulated expression of microRNA (miR)-221 is associated with downregulation of p27 and subsequent increased cell proliferation in a variety of human cancers. It is unknown whether miR-221 mimics could trigger neoplastic cellular proliferation.
Yue Zhou, Denise YuEn Ng, Arthur Mark Richards, Peipei Wang   +3 more
doaj   +1 more source

Cortical bone assessed with clinical computed tomography at the proximal femur. [PDF]

, 2014
Hip fractures are the most serious of all fragility fractures in older people of both sexes. Trips, stumbles, and falls result in fractures of the femoral neck or trochanter, and the incidence of these two common fractures is increasing worldwide as ...
Beck, Black, Black, Black, Bligh, Borggrefe, Bousson, Bousson, Boyce, Brett, Brixen, Camp, Carballido-Gamio, Carballido-Gamio, Carballido-Gamio, Carpenter, Chen, Cheng, Cooper, Crabtree, Cristofolini, Currey, Davis, de Bakker, Eastell, Engelke, Engelke, Engelke, Feik, Genant, Genant, Hangartner, Hangartner, Hangartner, Holzer, Huber, Ito, Ito, Ito, Jee, Johannesdottir, Johannesdottir, Kang, Kang, Kang, Kaptoge, Keaveny, Keaveny, Koivumäki, Koivumäki, Lang, Lang, Lewiecki, Li, Link, Lotz, Manske, Marshall, Marshall, Mautalen, Mayhew, McClung, McClung, McClung, Newman, Nicks, Parker, Poole, Poole, Poole, Power, Prevrhal, Prevrhal, Pulkkinen, Rho, Riggs, Sambrook, Seeman, Seeman, Seeman, Sigurdsson, Singer, Smith, Szulc, Treece, Treece, Treece, Van Rietbergen, Verhulp, Yang, Yang, Yang, Yang, Zebaze   +93 more
core   +2 more sources

Amalgamated reference data for size-adjusted bone densitometry measurements in 3598 children and young adults – the ALPHABET study [PDF]

, 2016
The increasing use of dual energy X-ray absorptiometry (DXA) in children has led to the need for robust reference data for interpretation of scans in daily clinical practice.
Adams, J.E., Ahmed, S.F., ALPHABET Study Team, ., Arundel, P., Bebbington, N.A., Bishop, N.J., Crabtree, N.J., Fewtrell, M.S., Högler, W., Mughal, M.Z., Shaw, N.J., Treadgold, L.A., Ward, K.A.   +12 more
core   +5 more sources

THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE

Klinicist, 2015
The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the
S. Sagalovsky, P. Kunze, M. Schönert
doaj   +1 more source

Cathepsin K inhibition induces Raptor destabilization and mitochondrial dysfunction via Syk/SHP2/Src/OTUB1 axis-mediated signaling

Cell Death and Disease, 2023
The Raptor signaling pathway is a critical point of intervention in the invasion and progression of cancer. The non-receptor tyrosine kinase Src-mediated phosphorylation of OTUB1-Y26 plays a critical role in Raptor stabilization, whereas cathepsin K ...
Seung Un Seo, Seon Min Woo, Taeg Kyu Kwon   +2 more
doaj   +1 more source

Uma visão geral sobre o tratamento da osteoporose pós-menopausa [PDF]

, 2014
Osteoporosis is a worldwide health problem related to the aging of the population, and it is often underdiagnosed and undertreated. It is related to substantial morbidity, mortality and impairment of the quality of life.
Lazaretti-Castro, Marise, Maeda, Sergio Setsuo   +1 more
core   +3 more sources