Results 51 to 60 of about 1,795 (205)
Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis. [PDF]
, 2020 The surgeon general of the USA defines osteoporosis as "a skeletal disorder characterized by compromised bone strength, predisposing to an increased risk of fracture." Measuring bone strength, Biomechanical Computed Tomography analysis (BCT), namely ...
Bouxsein, ML +6 more
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Pharmacological advances in the management of osteoporosis
Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012 Osteoporosis is a worldwide health problem with a high prevalence. Agents for the treatment of osteoporosis are classified as antiresorptives, anabolic agents and drugs with combined anabolic and anti-resorptive actions.
Noel P Somasundaram, MSA Cooray
doaj +1 more source
Redox Biology, 2020 Cathepsin K (Cat K) is expressed in cancer cells, but the effect of Cat K on apoptosis is still elusive. Here, we showed that inhibition of Cat K sensitized the human carcinoma cells to anti-cancer drug through up-regulation of Bim.
Seung Un Seo +8 more
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Bisphosphonates, atherosclerosis and vascular calcification: Update and systematic review of clinical studies [PDF]
, 2017 Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of ...
Caffarelli, Carla +3 more
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JBMR Plus, 2021 Osteoporosis and cardiovascular (CV) disease share common risk factors and pathophysiology. Low bone mineral density (BMD) and fractures appear to increase the risk for multiple CV diseases.
Alexander J Rodríguez, Bo Abrahamsen
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Cathepsin K: The Action in and Beyond Bone
Frontiers in Cell and Developmental Biology, 2020 Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.
Rongchen Dai +7 more
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Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity [PDF]
Restorative Dentistry & Endodontics, 2019 ObjectivesRoot resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to assess effects of a
Hee-Sun Kim +4 more
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Emerging therapies for osteoporosis
Reumatismo, 2014 Currently available drugs for the treatment of osteoporosis can still be improved in terms of pharmacokinetics, pharmacodynamics and management. New approaches for the development of innovative drugs are possible thanks to our increasing understanding of
G. Minisola, A. Iuliano, I. Prevete
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Native proteins in organic chemistry. Recent achievements in the use of non hydrolytic enzymes for the synthesis of pharmaceuticals [PDF]
, 2016 Financial support by the Spanish Ministerio de Economia y Competitividad (MINECO) through the CTQ-2013-44153-P project is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +2 more
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Odanacatib: An Emerging Novel Treatment Alternative for Postmenopausal Osteoporosis
Women's Health, 2015 Odanacatib represents a novel treatment option in the approach of postmenopausal women. Postmenopausal women with osteoporosis experience a disturbance in bone remodeling wherein bone resorption exceeds bone formation. Cathepsin K is a lysosomal cysteine protease found primarily in osteoclasts that plays a major role in the breakdown of bone via its ...
Thomas C, Schultz +3 more
openaire +2 more sources