Results 61 to 70 of about 1,795 (205)

Chemoenzymatic Synthesis of an Odanacatib Precursor through a Suzuki‐Miyaura Cross‐Coupling and Bioreduction Sequence

ChemCatChem, 2019
A series of 1‐aryl‐2,2,2‐trifluoroethanones has been chemically synthesized to later study their bioreduction using stereocomplementary alcohol dehydrogenases (ADHs).
Daniel González‐Martínez, V. Gotor, V. Gotor‐Fernández   +2 more
semanticscholar   +1 more source

Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells

BMC Molecular and Cell Biology, 2020
Background Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phosphatase activity.
Anja Reithmeier, Maria Norgård, Barbro Ek-Rylander, Tuomas Näreoja, Göran Andersson   +4 more
doaj   +1 more source

Effects of 24 months of treatment with romosozumab followed by 12 months of denosumab or placebo in postmenopausal women with low bone mineral density : a randomized, double-blind, phase 2, parallel group study [PDF]

, 2018
Over 12 months, romosozumab increased bone formation and decreased bone resorption, resulting in increased bone mineral density (BMD) in postmenopausal women with low BMD (NCT00896532).
Binkley, Bone, Cosman, Cummings, Harrington, Heiss, Langdahl, Leder, Li, Li, McClung, Ominsky, Padhi, Papapoulos, Recknor, Saag, van Bezooijen, Wasnich   +17 more
core   +2 more sources

Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance

MedComm, Volume 6, Issue 11, November 2025.
This graphical abstract illustrates the immunomodulation of chronic wounds through various therapeutic approaches aimed at regulating the immune response to promote healing. ABSTRACT Chronic wounds—such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)—pose a serious clinical challenge due to their prolonged ...
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar, Thomas Biedermann   +3 more
wiley   +1 more source

Fluorination methods in drug discovery [PDF]

, 2016
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio, Postigo, Jose Alberto, Yerien, Damián Emilio   +2 more
core   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, Volume 12, Issue 34, September 11, 2025.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Comparative genomics of the major parasitic worms [PDF]

, 2018
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development.
A Bairoch, A Chang, A Diaz, A Gaulton, A Harder, A Morgulis, A Prior, A Stamatakis, AA Rehman, AC Darby, AJ Vilella, AK Jones, AL Williamson, AL Williamson, AR Quinlan, AU Rao, AV Protasio, B Chevreux, B Wu, BJ Foth, BJ Haas, BW Li, C Cantacessi, C Casaravilla, C Claudel-Renard, C Dieterich, C Godel, C Holt, C Wu, C. elegans Sequencing Consortium., CA Desjardins, CH Opperman, CL Valentim, CM Taylor, CM Taylor, CW Dunn, D Ellinghaus, D Miranda-Saavedra, DP Knox, DR Laetsch, DR Zerbino, DS Zarlenga, E Courtot, E Ghedin, E Nagayasu, E Watson, EJ Pearce, F Ronquist, FA Kondrashov, G Coakley, G Cochrane, G Gremme, G Krautz-Peterson, G Parra, G Zhang, G.B.D. 2015 Disease and Injury Incidence and Prevalence Collaborators., GE Tusnady, H Gong, H Li, H Tobler, HM Bennett, I Korf, IJ Tsai, IJ Tsai, International Human Genome Sequencing Consortium., J Butler, J Castresana, J Charlier, J Pagel Van Zee, J Soding, J Srinivasan, J Wang, JA Cotton, JA Cotton, JA Rodrigues, JD Bendtsen, JD Hadfield, JH McKerrow, JJ Vermeire, JK Bonfield, JM Martin-Duran, JP Hewitson, JP Hewitson, JT Jones, JT Simpson, JT Simpson, K Howe, K Katoh, K MacDonald, KL Howe, KL Howe, L Anderson, L Kall, LF Furtado, LM Parsons, M Boetzer, M Boetzer, M Cancela, M Delcroix, M Hunt, M Kanehisa, M Lynch, M Margulies, M Mitreva, M Nei, M Shapira, M Srivastava, M Srivastava, M Stanke, MD Adams, MF Rey-Burusco, MG Grabherr, MK Cathcart, MM Albarqi, MN Price, MR Crusoe, MR Esteban, MR Martzen, MS Duffy, ND Rawlings, ND Young, NG Ntalli, NH Putnam, O Simakov, P Jones, PD Karp, PH Schiffer, R Caspi, R Hoeven van der, R Laing, R Real, R Santos, R She, R Tyagi, R Tyagi, R Wehrens, RC Edgar, RD Finn, RM Kaplan, S Capella-Gutierrez, S Hunter, S Kumar, S Velankar, SF Altschul, SK Buxton, SM Robb, SN McNulty, SN McNulty, SS Hung, T Britton, T Kikuchi, T Lynagh, T Sterling, T Tatusova, TD Otto, TD Otto, The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium., V Lombard, V Ter-Hovhannisyan, V Vasiliou, VL Hunt, W Xue, X Wang, Y Moriya, Y Satou, YT Tang   +165 more
core   +10 more sources

Osteoclasts’ ability to generate trenches rather than pits depends on high levels of active cathepsin K and efficient clearance of resorption products [PDF]

, 2020
Until recently, it was well-accepted that osteoclasts resorb bone according to the resorption cycle model. This model is based on the assumption that osteoclasts are immobile during bone erosion, allowing the actin ring to be firmly attached and thereby ...
Delaissé, Jean-Marie, Goldberg Borggaard, Xenia, Pirapaharan, Dinisha Cyril, Søe, Kent   +3 more
core   +1 more source

Immune regulatory and anti‐resorptive activities of tanshinone IIA sulfonate attenuates rheumatoid arthritis in mice

British Journal of Pharmacology, Volume 181, Issue 24, Page 5009-5027, December 2024.
Background and Purpose Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction. Current treatments are helpful in RA remission, but strong immunosuppressive activity and patient resistance are clinical issues.
Preety Panwar, Pierre Marie Andrault, Dipon Saha, Dieter Brömme   +3 more
wiley   +1 more source

Odanacatib: a possible new therapeutic option for the treatment of osteoporosis [PDF]

International Journal of Clinical Rheumatology, 2012
Producción ...
Pérez Castrillon, José Luis, Pinacho Peláez, Florentino, Ruiz Mambrilla, Marta María, Dueñas Laita, Antonio   +3 more
openaire   +2 more sources